Healing Effect of Bee Venom Cream to Full-Thickness Skin Wound in Rabbits

다국어 초록 (Multilingual Abstract)

Experiments were conducted in order to assess the healing effect of bee venom (BV) cream
on full-thickness skin wounds in rabbits. BV cream was compared with silver sulfadiazine (SS) as a topical
medicament against a control on experimentally created full-thickness wounds. Two wounds measuring
2 × 2 cm were created bilaterally (four wounds/rabbit) on the dorsolateral aspect of the trunk of seven New
Zealand white rabbits. Wound treatments were evenly distributed on four sites, using a Latin square design.
The contact layer of wounds was treated with physiological saline (control), SS cream, and BV cream over a
period of 28 days. Assessment of wound healing was based on scab hardness, wound exudates, wound area,
unepithelialized granulation tissue, and histopathological findings. Topical application of BV and SS creams
to wounds resulted in reduced inflammation, debridement of necrotic tissue, and promoted granulation and
epithelialization. Wound healing was faster, with statistical significance in BV and SS treatments, compared
to the control (P<0.05). Treatment with BV evoked an anti-inflammation effect in a rabbit model. BV cream
produced a wound healing effect similar to that of commercially available SS cream. Anti-inflammation
effect as a topical treatment with BV cream appears to be better than that with SS cream. These results
suggest that topical application of BV cream may be an alternative treatment for full-thickness skin wounds.