Natural course of HPV positive women in Atypical Squamous Cells of Undetermined Significance or Low-Grade Squamous Intraepithelial Lesion and association of HPV genotype: HPV cohort study = Natural course of HPV positive women in Atypical Squamous Cells of Undetermined Significance or Low-Grade Squamous Intraepithelial Lesion and association of HPV genotype: HPV cohort study

국문 초록 (Abstract)

목적: Human Papillomavirus (HPV) is known as prevalent sexually transmitted virus causing cytological abnormalities. More than 100 HPVs have been sequenced, among which approximately 15 types are classified as oncogenic types. Although Atypical Squamous Cells of Undetermined Significance (ASC-US) or Low-Grade Squamous Intraepithelial Lesion (LSIL) are the most frequent cytological alteration, association of HPV genotype and abnormal cervical cytology of either ASC-US or LSIL is uncertain. The aim of this study is to investigate nature of progression, persistence or regression according to HPV genotype in women with both HPV infection and cytological abnormality of either ASC-US or LSIL.
방법: A cohort study with ASC-US or LSIL cytology was accomplished between November 2011 and June 2014 at Dongsan medical center, Keimyung University. 198 HPV positive women with abnormal cervical cytology (ASC-US or LSIL) were included for our study. The follow-up lasted at least two years and enrolled patients received cervical cytology and HPV DNA testing every six months
결과: Among enrolled 198 patients, 168 patients were followed in 24 months study. Cervical cytology alterations showed progression in 22.9% of women, persistence in 9.3%, and regression in 67.8% of women at 24 months. According to the subdivision of HPV genotype, all of 10 patients in low risk HPV showed regression. On the other hand, high risk and mixed infection of HPV showed progression in 19.8% (high risk HPV) and 38.5% (mixed HPV) of women. The most prevalent HPV genotypes was 16 (15.8%), 53 (13.3%), 58 & 51 (10.9%) and 52 (10.2%). In the high oncogenic types (types 16 and 18), there was 52.9% (HPV 16) and 37.5% (HPV 18) progression in lesions.
결론: In our study, HPV 16 was the most frequent genotype found in women ASC-US or LSIL. The progression rate was positive correlated to infection to the high oncogenic type (types 16 and 18). The 50’s number of HPV genotype was frequent in women with ASC-US and LSIL.