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      KCI등재후보

      제대혈 염증성반응증후군의 In Vitro 분석 = In Vitro Analysis of Fetal Inflammatory Response Syndrome Using Human Umbilical Cord Blood

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      https://www.riss.kr/link?id=A106916599

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      다국어 초록 (Multilingual Abstract)

      Fetal inflammatory response syndrome is a multisystemic disorder, defined by elevated interleukin-6 (IL-6) in fetal plasma and associated with preterm delivery and adverse neonatal outcomes. Recent evidences indicate that the elevated concentration of matrix metalloproteinase-8 (MMP-8) is associated with fetal inflammatory response syndrome. Nuclear factor kappa B (NF-κB), has central roles in human immune response. In this study, we made in vitro model of fetal inflammatory response syndrome using lipopolysaccharide (LPS) stimulation to cord blood. The purpose of this study was to demonstrate that LPS induces a release of IL-6 and MMP-8 as well as NF-κB in cord blood. LPS stimulation increased the expression of NF-κB in a time dependent manner. MMP-8 level was significantly correlated with IL-6 level. All these results directly support that IL-6 and MMP-8 could be a useful marker for the diagnosis of fetal inflammatory response syndrome.
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      Fetal inflammatory response syndrome is a multisystemic disorder, defined by elevated interleukin-6 (IL-6) in fetal plasma and associated with preterm delivery and adverse neonatal outcomes. Recent evidences indicate that the elevated concentration of...

      Fetal inflammatory response syndrome is a multisystemic disorder, defined by elevated interleukin-6 (IL-6) in fetal plasma and associated with preterm delivery and adverse neonatal outcomes. Recent evidences indicate that the elevated concentration of matrix metalloproteinase-8 (MMP-8) is associated with fetal inflammatory response syndrome. Nuclear factor kappa B (NF-κB), has central roles in human immune response. In this study, we made in vitro model of fetal inflammatory response syndrome using lipopolysaccharide (LPS) stimulation to cord blood. The purpose of this study was to demonstrate that LPS induces a release of IL-6 and MMP-8 as well as NF-κB in cord blood. LPS stimulation increased the expression of NF-κB in a time dependent manner. MMP-8 level was significantly correlated with IL-6 level. All these results directly support that IL-6 and MMP-8 could be a useful marker for the diagnosis of fetal inflammatory response syndrome.

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      참고문헌 (Reference)

      1 Cunningham, F. G., "Williams Obstetrics" McGraw-Hill 2001

      2 Manimtim, W. M., "Ureaplasma urealyticum modulates endotoxin-induced cytokine release by human monocytes derived from preterm and term newborns and adults" 69 (69): 3906-3915, 2001

      3 Park, J. S., "The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis" 185 (185): 1156-1161, 2001

      4 Belt, A. R., "The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells" 181 (181): 359-366, 1999

      5 Gomez, R., "The fetal inflammatory response syndrome" (179) : 194-202, 2000

      6 Kawano, Y., "The effect of dexamethasone on expression of mitogen-induced cyclooxygenase-2 mRNA by amnion-derived(WISH)cells" 98 (98): 40-45, 2001

      7 Romero, R., "The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and gram stain in patients with preterm labor and intact membranes" 169 (169): 805-816, 1993

      8 Hacker, H., "Signal transduction pathways activated by CpG-DNA" (247) : 77-92, 1999

      9 Papi, A., "Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-kappaBmediated transcription" 274 (274): 9707-9720, 1999

      10 Schettler, A., "Release of proteinases from stimulated polymorphonuclear leukocytes. Evidence for subclasses of the main granule types and their association with cytoskeletal components" 197 (197): 197-202, 1991

      1 Cunningham, F. G., "Williams Obstetrics" McGraw-Hill 2001

      2 Manimtim, W. M., "Ureaplasma urealyticum modulates endotoxin-induced cytokine release by human monocytes derived from preterm and term newborns and adults" 69 (69): 3906-3915, 2001

      3 Park, J. S., "The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis" 185 (185): 1156-1161, 2001

      4 Belt, A. R., "The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells" 181 (181): 359-366, 1999

      5 Gomez, R., "The fetal inflammatory response syndrome" (179) : 194-202, 2000

      6 Kawano, Y., "The effect of dexamethasone on expression of mitogen-induced cyclooxygenase-2 mRNA by amnion-derived(WISH)cells" 98 (98): 40-45, 2001

      7 Romero, R., "The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and gram stain in patients with preterm labor and intact membranes" 169 (169): 805-816, 1993

      8 Hacker, H., "Signal transduction pathways activated by CpG-DNA" (247) : 77-92, 1999

      9 Papi, A., "Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-kappaBmediated transcription" 274 (274): 9707-9720, 1999

      10 Schettler, A., "Release of proteinases from stimulated polymorphonuclear leukocytes. Evidence for subclasses of the main granule types and their association with cytoskeletal components" 197 (197): 197-202, 1991

      11 Przemysław, L., "Molecular mechanism of curcumin action in signaling pathways : Review of the latest research" 34 (34): 1154-1165, 2020

      12 Kuprash, D. V., "Molecular and Cellular Mechanisms of Inflammation" 81 (81): 1477-1480, 2016

      13 Woessner, J. F, "Matrix metalloproteinases and their inhibitors in connective tissue remodeling" 5 (5): 2145-2154, 1991

      14 Chen, H. Y., "Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients" 27 (27): 366-369, 2000

      15 Hanemaaijer, R., "Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline" 272 (272): 31504-31509, 1997

      16 Sica, A., "Interaction of NF-kappa B and NFAT with the interferon-gamma promoter" 174 (174): 30412-30420, 1997

      17 Amory, J. H., "Increased tumor necrosis factor-alpha production after lipopolysaccharide stimulation of whole blood in patients with previous preterm delivery complicated by intra-amniotic infection or inflammation" 185 (185): 1064-1067, 2001

      18 Janeway, C. A., "Immunobiology" Churchill Livingstone 2001

      19 Sirota, L., "Effect of indomethacin on IL-1beta, IL-6and TNFalpha production by mononuclear cells of preterm newborns and adults" 89 (89): 331-335, 2000

      20 Van der Linden, M. W., "Determination of tumour necrosis factor-alpha and interleukin-10production in a whole blood stimulation system: assessment of laboratory error and individual variation" 218 (218): 63-71, 1998

      21 Yoon, B. H., "Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes" 185 (185): 1130-1136, 2001

      22 Yoon, B. H., "Clinical implications of detection of Ureaplasma urealyticum in the amniotic cavity with the polymerase chain reaction" (183) : 1130-1137, 2000

      23 Moon, J. B., "Amniotic fluid matrix metalloproteinase-8 and the development of cerebral palsy" 30 (30): 301-306, 2002

      24 Kim, C. J., "Acute chorioamnionitis and funisitis: definitio, pathologic features, and clinical significance" 213 (213): S29-S52, 2015

      25 Romero, R., "A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition" 179 (179): 186-193, 1998

      26 Satoshi, Y., "17OHP-C in patients with spontaneous preterm labor and intact membranes:is there an effect according to the presence of intra-amniotic inflammation?" 80 (80): 12867-12878, 2018

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