This study concerns an observation noted in changes of. serum ceruloplasmin after hepatectomy (removal of 70% of the liver) in rats. These data were compared with those of several values of liver function tests and incorporation rates of amino acid mi...
This study concerns an observation noted in changes of. serum ceruloplasmin after hepatectomy (removal of 70% of the liver) in rats. These data were compared with those of several values of liver function tests and incorporation rates of amino acid mixed-^(14)C into serum protein in the same rats. After partial hepatectomy of the rats, serum ceruloplasmin contents were significantly increased in the span of two to three days (peak on the third day). However, the values returned to normal after six days. The levels of alkaline phosphatase in the serum of same rats significantly increased after hepatectomy to reach its peak on the second day and these levels continued to be high throughout the 10 days. The activity of serum glutamic pyruvic transaminase was also elevated 12 hours to two days following partial hepatectomy in rats. No significant changes in total bilirubin contents were noted throughout the experiments. Serum total protein contents and incorporation of amino acid mixed-^(14)C into serum protein were significantly decreased in the regenerating stage. The most decreased values were seen after two days in incorporation rate and three days in serum total protein contents.