Background: Some gastric subepithelial tumors (SETs) have malignant potential. But, pathologic diagnosis is challenging. Recently, there are increasing reports about endoscopic resection applied to resect gastrointestinal SETs. We aimed to determine t...
Background: Some gastric subepithelial tumors (SETs) have malignant potential. But, pathologic diagnosis is challenging. Recently, there are increasing reports about endoscopic resection applied to resect gastrointestinal SETs. We aimed to determine the effi cacy and safety of endoscopic resection for the removal of gastric SETs. Methods: From January 2006 to December 2013, 51 patients were included in this study. They underwent routine upper gastrointestinal endoscopy and endoscopic ultrasonography (EUS). endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) was used to remove gastric SETs. The results of complete resection rates and complications were analyzed. Results: The ratio of male to female was 18:33 (35.3%:64.7%), and the mean age was 55.6 ± 11.1 years. The median tumor size measured by EUS was 14.2 mm (range 4-80 mm), and the median procedure time was 25 minutes (range 6-140 minutes). En bloc resection was achieved in 44 cases (86.3%) and histologic complete resection (CR) was done in 42 (82.4%). Complete resection was considerably low when tumor originate from proper muscle layer (4/8, 50.0%) than submucosal layer (38/43, 88.4%, p=0.019). Histologic diagnosis was obtained in all cases, including 16 carcinoid tumors, 12 infl ammatory fi brinoid polyps, 6 gastrointestinal stromal tumors and 17 others. Signifi cant bleeding during procedure was occurred in three cases and delayed bleeding was occurred in one case. Perforation was detected in 2 cases. The mean follow-up period was 22 months and any recurrence was not identifi ed. Conclusions: Endoscopic resection is safe and effective method to resect and acquire a histologic diagnosis of gastric SETs. However, to achieve en bloc excision for completely curative aim, novel endoscopic procedure including endoscopic full-thickness resection or conventional surgical wedge resection would also be considered, when tumor originate from proper muscle layer.