Poster Session : PS 0769 ; Upper GI Tract : The Effectiveness of a Novel Submucosal Lifting Gel for Performing Endoscopic Mucosal Resection after Precutting (EMR-P) in Large Lesion: An Animal PilotStudy = Poster Session : PS 0769 ; Upper GI Tract : The Effectiveness of a Novel Submucosal Lifting Gel for Performing Endoscopic Mucosal Resection after Precutting (EMR-P) in Large Lesion: An Animal PilotStudy

다국어 초록 (Multilingual Abstract)

Background: The submcosal lifting gel (Cook Medical) is a novel injectate for submucosal lifting of gastrointestinal lesions. It has been proven to be an effective lifting solution to facilitate tissue resection and auto-dissection of submucosal layer after its submucosal injection. The aim of this study was to evaluate the effi cacy of a novel submucosal lifting gel for performing EMR-P in the case of large lesion. Methods: This study was designed as a prospective, controlled, animal, and pilot study. A total of 31 artificial lesions were created on body of stomach by electrocautery marking with endoscopic ruler in fi ve live micro-pigs. Results: All 31 lesions were successfully resected by EMR-P method with a new submucosal lifting gel by two experienced endoscopists in 3 micro-pigs. The long axis of the mean size of resected specimens was 3.7 (± 0.3) cm, 4.6 (± 0.5) cm, and 5.1 (± 0.7) cm in the group 1, 2 and 3 respectively. The mean circumferential resection time was signifi cantly longer in the group 3 in comparison with group 1 and 2. The mean total procedure time and amount of injection were signifi cant difference between three groups. However, the mean submucosal injection time was no signifi cant difference three groups. The en bloc rate of each group was 100% (6/6), 66.7% (4/6), and 40% (2/5) in the group 1, 2, and 3 respectively. There was a perforation during circumferential cutting in group 2. However, there was no immediate bleeding and perforation after EMR Conclusions: In a porcine model, a new submucosal lifting gel seems to improve the en bloc rate for performing EMR-P in large lesion, especially 3 cm in diameter.