Aminoglycoside 항생물질을 생성하는 Streptomycetes 와 Micromonospora spp 들의 Aminoglycoside 항생물질 변형효소에 관한 연구 = Aminoglycoside Antibiotic Modifying Enzymes in Aminoglycoside Producing Streptomycetes and Micromonospora spp .

다국어 초록 (Multilingual Abstract)

The cell free extracts of streptomycin producers, 7 strains of S. griseus and 1 strain of S. galbus inactivate streptomycin by phosphorylation, and the resistant mechanism against streptomycin by phosphorylation seems to be popular in streptomycin producing organisms. The cell free extracts of neomycin and paromomycin producers, S. fradiae and S. rimosus forma paromomycinus inactivate neomycin not only by phosphorylation, but also by acetylation. The cell free extract of a kanamycin producer. S. kanamyceticus (IFO 13414) inactivates neomycin by phosphorylation and/or by acetylation. However it does not inactivate kanamycin by phosphorylation but does by acetylation. The cell free extracts of the other kanamycin producer, S. kanamyceticus (NRRL 2535) does not show any inactivation of neomycin as well as kanamycin by phosphorylation or by acetylation, although it shows strong resisance against the antibiotics. The cell free extracts of Micromonospora spp.. producers of gentamicin or sisomicin which show resistance against gentamicin, kanamycin and tobramycin do not possess any phosphorylating or acetylating enzymes for the aminoglycoside antibiotics employed in this study. The Streptomycetes producing aminoglycoside antibiotics seem to have characteristic resistance mechanisms against the antibiotics produced by themselves and against other similar antibiotics.