지구성 운동이 쥐 혈청 IGF-1, IGFBP-3 수준과 골격근 형태별 GLUT-4에 미치는 영향

다국어 초록 (Multilingual Abstract)

We investigate the effects of 12wk treadmill exercise on the skeletal muscle GLUT-4 protein, serum glucose, insulin, IGF-1, IGFBP-Ⅲ and lipids in the insulin resistant obese Zucker rats(fa/fa). Male obese Zucker rats either remained sedentary(fa/fa, n=7), and performed treadmill exercise(fa/fa, n=7) for 12wk. During oral glucose tolerance test(OGTT), treadmill exercise resulted in a significant lowering of the glucose, insulin and TC, TG, LDL-C responses compared with sedentary controls. Treadmill exercise increased serum IGF-1, IGF-BP-III and insulin-regulated glucose transporter(GLUT-4) in isolated soleus, plantaris muscle. The greatest expressions in GLUT-4 protein in these muscles were observed in the treadmill exercise group. Thus, enhancement in glucose transport in soleus and plantaris muscle due to treadmill exercise was related to enhanced serum IGF-1, IGF-BP-III and GLUT-4 protein and decrease glucose, insulin and TC, TG, LDL-C. These results suggest that treadmill exercise may reduce the risk of associated diseases including diabetes and coronary heart disease.