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      Remarkable impact of amino acids on ginsenoside transformation from fresh ginseng to red ginseng

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      https://www.riss.kr/link?id=A106831656

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      다국어 초록 (Multilingual Abstract) kakao i 다국어 번역

      Background: Amino acids are one of the major constituents in Panax ginseng, including neutral aminoacid, acidic amino acid, and basic amino acid. However, whether these amino acids play a role in ginsenosideconversion during the steaming process has not yet been elucidated.
      Methods: In the present study, to elucidate the role of amino acids in ginsenoside transformation fromfresh ginseng to red ginseng, an amino acids impregnation pretreatment was applied during thesteaming process at 120 C. Acidic glutamic acid and basic arginine were used for the acid impregnationtreatment during the root steaming. The ginsenosides contents, pH, browning intensity, and free aminoacids contents in untreated and amino acidetreated P. ginseng samples were determined.
      Results: After 2 h of steaming, the concentration of less polar ginsenosides in glutamic acidetreatedP. ginseng was significantly higher than that in untreated P. ginseng during the steaming process. However,the less polar ginsenosides in arginine-treated P. ginseng increased slightly. Meanwhile, free aminoacids contents in fresh P. ginseng, glutamic acid-treated P. ginseng, and arginine-treated P. ginsengsignificantly decreased during steaming from 0 to 2h. The pH also decreased in P. ginseng samples at hightemperatures. The pH decrease in red ginseng was closely related to the decrease in basic amino acidslevels during the steaming process.
      Conclusion: Amino acids can remarkably affect the acidity of P. ginseng sample by altering the pH value. Theywere the main influential factors for the ginsenoside transformation. These results are useful in elucidatingwhy andhowsteaming induces the structural change of ginsenoside in P. ginseng and also provides an effectiveand green approach to regulate the ginsenoside conversion using amino acids during the steaming process.
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      Background: Amino acids are one of the major constituents in Panax ginseng, including neutral aminoacid, acidic amino acid, and basic amino acid. However, whether these amino acids play a role in ginsenosideconversion during the steaming process has n...

      Background: Amino acids are one of the major constituents in Panax ginseng, including neutral aminoacid, acidic amino acid, and basic amino acid. However, whether these amino acids play a role in ginsenosideconversion during the steaming process has not yet been elucidated.
      Methods: In the present study, to elucidate the role of amino acids in ginsenoside transformation fromfresh ginseng to red ginseng, an amino acids impregnation pretreatment was applied during thesteaming process at 120 C. Acidic glutamic acid and basic arginine were used for the acid impregnationtreatment during the root steaming. The ginsenosides contents, pH, browning intensity, and free aminoacids contents in untreated and amino acidetreated P. ginseng samples were determined.
      Results: After 2 h of steaming, the concentration of less polar ginsenosides in glutamic acidetreatedP. ginseng was significantly higher than that in untreated P. ginseng during the steaming process. However,the less polar ginsenosides in arginine-treated P. ginseng increased slightly. Meanwhile, free aminoacids contents in fresh P. ginseng, glutamic acid-treated P. ginseng, and arginine-treated P. ginsengsignificantly decreased during steaming from 0 to 2h. The pH also decreased in P. ginseng samples at hightemperatures. The pH decrease in red ginseng was closely related to the decrease in basic amino acidslevels during the steaming process.
      Conclusion: Amino acids can remarkably affect the acidity of P. ginseng sample by altering the pH value. Theywere the main influential factors for the ginsenoside transformation. These results are useful in elucidatingwhy andhowsteaming induces the structural change of ginsenoside in P. ginseng and also provides an effectiveand green approach to regulate the ginsenoside conversion using amino acids during the steaming process.

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      참고문헌 (Reference)

      1 남기열, "홍삼과 백삼의 비교 고찰" 고려인삼학회 29 (29): 1-18, 2005

      2 Naval MV, "Value of highperformance liquid chromatographic analysis of amino acids in the determination of Panax ginseng radix extract effect in cultured neurons" 1121 : 242-247, 2006

      3 배은아, "Transformation of Ginseng Saponins to Ginsenoside Rh2 by Acids and Human Intestinal Bacteria and Biological Activities of Their Transformants" 대한약학회 27 (27): 61-67, 2004

      4 Cho EJ, "The effect of steaming on the free amino acid contents and antioxidant activity of Panax ginseng" 107 : 876-882, 2008

      5 Yuan H, "The comparison of the contents of sugar, amadori, and heyns compounds in fresh and black garlic" 81 : 1662-1668, 2016

      6 Lee YJ, "The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing" 18 : 4515-4520, 2008

      7 Eun-Hwa Park, "Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed American ginseng on human gastric cancer cell" 고려인삼학회 38 (38): 22-27, 2014

      8 Xie YY, "Steaminginduced chemical transformations and holistic quality assessment of red ginseng derived from Panax ginseng by means of HPLC-ESI-MS/MSn-based multicomponent quantification fingerprint" 60 : 8213-8224, 2012

      9 Kim WY, "Steaming of ginseng at high temperature enhances biological activity" 63 : 1702-1704, 2000

      10 Kim JH, "Renoprotective effects of Maillard reaction products generated during heat treatment of ginsenoside Re with leucine" 143 : 114-121, 2014

      1 남기열, "홍삼과 백삼의 비교 고찰" 고려인삼학회 29 (29): 1-18, 2005

      2 Naval MV, "Value of highperformance liquid chromatographic analysis of amino acids in the determination of Panax ginseng radix extract effect in cultured neurons" 1121 : 242-247, 2006

      3 배은아, "Transformation of Ginseng Saponins to Ginsenoside Rh2 by Acids and Human Intestinal Bacteria and Biological Activities of Their Transformants" 대한약학회 27 (27): 61-67, 2004

      4 Cho EJ, "The effect of steaming on the free amino acid contents and antioxidant activity of Panax ginseng" 107 : 876-882, 2008

      5 Yuan H, "The comparison of the contents of sugar, amadori, and heyns compounds in fresh and black garlic" 81 : 1662-1668, 2016

      6 Lee YJ, "The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing" 18 : 4515-4520, 2008

      7 Eun-Hwa Park, "Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed American ginseng on human gastric cancer cell" 고려인삼학회 38 (38): 22-27, 2014

      8 Xie YY, "Steaminginduced chemical transformations and holistic quality assessment of red ginseng derived from Panax ginseng by means of HPLC-ESI-MS/MSn-based multicomponent quantification fingerprint" 60 : 8213-8224, 2012

      9 Kim WY, "Steaming of ginseng at high temperature enhances biological activity" 63 : 1702-1704, 2000

      10 Kim JH, "Renoprotective effects of Maillard reaction products generated during heat treatment of ginsenoside Re with leucine" 143 : 114-121, 2014

      11 Liu Z, "Remarkable impact of acidic ginsenosides and organic acids on ginsenoside transformation from fresh ginseng go red ginseng" 64 : 5389-5399, 2016

      12 Wang JS, "Quality and safety of Chinese herbal medicines guided by a systems biology perspective" 126 : 31-41, 2009

      13 Choi IS, "Physicochemical and antioxidant properties of black garlic" 19 : 16811-16823, 2014

      14 Ma LY, "New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng" 25 : 5321-5325, 2015

      15 Sun GZ, "Isolation and structure characterization of malonyl-notoginsenoside-R4 from the root of Panax ginseng" 28 : 1316-1318, 2007

      16 Ruan CC, "Isolation and characterization of a new ginsenoside from the fresh root of Panax Ginseng" 15 : 2319-2325, 2010

      17 Qi LW, "Isolation and analysis of ginseng : advances and challenges" 28 : 467-495, 2011

      18 Ha KS, "In vitro and in vivo antihyperglycemic effect of 2 amadori rearrangement compounds, arginyl-fructose and arginyl-fructosyl-glucose" 76 : H188-H193, 2011

      19 김교남, "Heat Processing Decreases Amadori Products and Increases Total Phenolic Content and Antioxidant Activity of Korean Red Ginseng" 한국식품영양과학회 13 (13): 1478-1484, 2010

      20 Qi LW, "Ginsenosides from American ginseng : chemical and pharmacological diversity" 72 : 689-699, 2011

      21 Park EK, "Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities" 133 : 113-120, 2004

      22 Wei Li, "Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis" MDPI AG 8 (8): 566-, 2016

      23 Rufián-Henares JA, "Functional properties of melanoidins : in vitro antioxidant, antimicrobial and antihypertensive activities" 40 : 995-1002, 2007

      24 Zhang XY, "Effects of temperature on the quality of black garlic" 96 : 2366-2372, 2016

      25 Ghafoor K, "Effects of high hydrostatic pressure on structure and colour of red ginseng(Panax ginseng)" 92 : 2975-2982, 2012

      26 Khan JK, "Determination of non-protein amino acids and toxins in Lathyrus by high-performance liquid chromatography with precolumn phenyl isothiocyanate derivatization" 687 : 113-119, 1994

      27 Kitts DD, "Demonstration of antioxidant and anti-inflammatory bioactivities from sugareamino acid Maillard reaction products" 60 : 6718-6727, 2012

      28 Liang TF, "Comprehensive NMR analysis of compositional changes of black garlic during thermal processing" 63 : 683-691, 2015

      29 Kim DY, "Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells" 57 : 10573-10578, 2009

      30 Mi Ra Lee, "Comparative Study of White and Steamed Black Panax ginseng, P. quinquefolium, and P. notoginseng on Cholinesterase Inhibitory and Antioxidative Activity" 고려인삼학회 36 (36): 93-101, 2012

      31 Liu ZQ, "Chemical insights into ginseng as a resource for natural antioxidants" 112 : 3329-3355, 2012

      32 Yukio Suzuki, "Arginyl-fructosyl-glucose and Arginyl-fructose, Compounds Related to Broming Reaction in the Model System of Steaming and Heat-drying Processes for the Preparation of Red Ginseng" 고려인삼학회 28 (28): 143-148, 2004

      33 Liu Z, "Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin" 145 : 233-240, 2013

      34 Zhao ZZ, "A unique issue in the standardization of Chinese materia medica : Processing" 76 : 1975-1986, 2010

      35 Zheng YN, "A new amino acid derivative from red ginseng" 7 : 7-10, 1998

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      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-04-07 학술지명변경 한글명 : 고려인삼학회지 -> Journal of Ginseng Research KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2004-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2003-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2001-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 3.97 1.04 2.93
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