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      K-WMS-IV 디자인 소검사의 임상적 유용성: 경도인지장애 환자의 수행 특징 = Clinical utility of the Design subtest of the K-WMS-IV: Visuo-spatial memory performance of the patients with mild cognitive impairment

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      다국어 초록 (Multilingual Abstract)

      This study was conducted to confirm the clinical utility of the Design subtest of the K-WMS-IV in detecting mild cognitive impairment, high risk of Alzheimer's dementia. We compared the performance of the patients with amnestic MCI to healthy controls in three subcomponents of Design, which were object, spatial, object-spatial binding memory. The results were as follows. First, amnestic MCI patients showed significantly lower performance in immediate spatial memory and object-location binding memory, and delayed object-location binding memory than healthy controls, whilst their object memory were intact. Second, immediate object-spatial binding memory was the only significant predictor on amnestic MCI in logistic regression analysis. Third, the Area Under the ROC Curve(AUCs) of the immediate spatial memory and object-spatial binding memory were 'fair', .71 and .74, respectively. In conclusion, the subcomponents score of the Design test was useful in detecting the characteristic pattern of the visuo-spatial memory performance in amnestic MCI, and these results suggested that the Design subtest of the K-WMS-IV could enhance the diagnostic accuracy.
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      This study was conducted to confirm the clinical utility of the Design subtest of the K-WMS-IV in detecting mild cognitive impairment, high risk of Alzheimer's dementia. We compared the performance of the patients with amnestic MCI to healthy controls...

      This study was conducted to confirm the clinical utility of the Design subtest of the K-WMS-IV in detecting mild cognitive impairment, high risk of Alzheimer's dementia. We compared the performance of the patients with amnestic MCI to healthy controls in three subcomponents of Design, which were object, spatial, object-spatial binding memory. The results were as follows. First, amnestic MCI patients showed significantly lower performance in immediate spatial memory and object-location binding memory, and delayed object-location binding memory than healthy controls, whilst their object memory were intact. Second, immediate object-spatial binding memory was the only significant predictor on amnestic MCI in logistic regression analysis. Third, the Area Under the ROC Curve(AUCs) of the immediate spatial memory and object-spatial binding memory were 'fair', .71 and .74, respectively. In conclusion, the subcomponents score of the Design test was useful in detecting the characteristic pattern of the visuo-spatial memory performance in amnestic MCI, and these results suggested that the Design subtest of the K-WMS-IV could enhance the diagnostic accuracy.

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      참고문헌 (Reference)

      1 최진영, "한국판 웩슬러 기억 검사(Korean Wechsler Memory Scale)" 한국심리 2012

      2 Choi, S. H., "한국판 Expanded Clinical Dementia Rating (CDR) 척도의 타당도" 19 (19): 585-591, 2001

      3 황순택, "한국 웩슬러 성인용 지능검사 4판(Kore an Wechsler Adult Intelligence Scale-IV; K-WAIS-IV)"

      4 최용옥, "급속한 기대수명 증가의 함의" KDI 2016

      5 Hampstead, B. M., "Where did I put that? Patients with amnestic mild cognitive impairment demonstrate widesp read reductions in activity during the encoding of ecologically relevant object-locatio n associations" 49 (49): 2349-2361, 2011

      6 Wechsler, D., "Wechsler memory scale–fourth edition (WMS-IV)" 2009

      7 Wechsler D., "Wechsler Memory Scale–Third Edition manual"

      8 Mitolo, M., "Visuospatial memory and neuroimaging correlates in mild cognitive impairment" 35 (35): 75-90, 2013

      9 Iachini, I., "Visuospatial mem ory in healthy elderly, AD and MCI : a review" 2 (2): 43-59, 2009

      10 Quental, N. B. M., "Visuospatial Function in Early Alzheimer’s Disease—The Use of the Visual Object and Space Perception (V OSP) Battery" 8 (8): e68398-, 2013

      1 최진영, "한국판 웩슬러 기억 검사(Korean Wechsler Memory Scale)" 한국심리 2012

      2 Choi, S. H., "한국판 Expanded Clinical Dementia Rating (CDR) 척도의 타당도" 19 (19): 585-591, 2001

      3 황순택, "한국 웩슬러 성인용 지능검사 4판(Kore an Wechsler Adult Intelligence Scale-IV; K-WAIS-IV)"

      4 최용옥, "급속한 기대수명 증가의 함의" KDI 2016

      5 Hampstead, B. M., "Where did I put that? Patients with amnestic mild cognitive impairment demonstrate widesp read reductions in activity during the encoding of ecologically relevant object-locatio n associations" 49 (49): 2349-2361, 2011

      6 Wechsler, D., "Wechsler memory scale–fourth edition (WMS-IV)" 2009

      7 Wechsler D., "Wechsler Memory Scale–Third Edition manual"

      8 Mitolo, M., "Visuospatial memory and neuroimaging correlates in mild cognitive impairment" 35 (35): 75-90, 2013

      9 Iachini, I., "Visuospatial mem ory in healthy elderly, AD and MCI : a review" 2 (2): 43-59, 2009

      10 Quental, N. B. M., "Visuospatial Function in Early Alzheimer’s Disease—The Use of the Visual Object and Space Perception (V OSP) Battery" 8 (8): e68398-, 2013

      11 Alescio-Lautier, B., "Visual and visuospatial short-term memory in mild cognitive impa irment and Alzheimer disease : role of attention" 45 (45): 1948-1960, 2007

      12 Kessels, R. P., "Varieties of human spatial memory : a meta-analysis on the effects of hippocampal lesions" 35 (35): 295-303, 2001

      13 Ally, B. A., "Using pictures and words to understand recognition memory deterioration in amnestic mild cognitive impairment and Alzheimer's disease : a review" 12 (12): 687-694, 2012

      14 Sperling, R. A., "Toward defining the preclinical stages of Alzheimer's disease : recomm endations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease" 7 (7): 280-292, 2011

      15 Bird, C. M., "Topographical short-term memory differentiates Alzheimer's disease from frontotemp oral lobar degeneration" 20 (20): 1154-1169, 2010

      16 Tam, J. W., "The role of processing speed in the Brief Visuospatial Memory Test-revised" 27 (27): 962-972, 2013

      17 Cho, M. J., "The prevalence and risk factors of dementia in the Korean elderly" 156 : 43-48, 2009

      18 Eichenbaum, H., "The medial temporal lobe and recognition memory" 30 : 123-152, 2007

      19 Dickerson, B. C., "The episodic memory system : neurocircuitry and disorders" 35 (35): 86-104, 2010

      20 Albert, M. S., "The diagnosis of mild cognitive impairment due to Alzheimer's diseas e : recommendations from the National Institute on Aging-Alzheimer's Association w orkgroups on diagnostic guidelines for Alzheimer's disease" 7 (7): 270-279, 2011

      21 Morris, J. C., "The Clinical Dementia Rating(CDR) : Current version and scoring rules" 43 (43): 2412-2414, 1993

      22 Lopes, M. A., "Systematic review of dementia prevalence-1994 to 2000. Dement" 1 (1): 230-240, 2007

      23 Alichniewicz, K. K., "Structural and functional neural correlates of visuospatial information processing in normal aging and amnestic mild cognitive impairment" 33 (33): 2782-2797, 2012

      24 DeIpolyi, A. R., "Spatial cognition and the human navigation network in AD and MCI" 69 (69): 986-997, 2007

      25 Shin, M. Y., "Risk for cognitive aging and dementia in the elderly Korean population with baseline low cognitive performance" Seoul National University 2017

      26 Yassuda, M., "Psychometric characteristics of the Rivermead Behavioural Memory Test(RBM T)as an early detection instrument for dementia and mild cognitive impairment in Brazil" 22 (22): 1003-1011, 2010

      27 Greiner M, "Principles and practical application of the receiveroperating characteristic analysis for diagnostic tests" 45 (45): 23-41, 2000

      28 Ally, B. A., "Preserved frontal mem orial processing for pictures in patients with mild cognitive impairment" 47 (47): 2044-2055, 2009

      29 Lezak, M. D., "Neuropsychological Asses sment: OUP USA"

      30 Petersen, R. C., "Mild cognitive impairment as a diagnostic entity" 256 (256): 183-194, 2004

      31 Petersen, R. C., "Mild cognitive impairment as a clinical entity and treatment target" 62 (62): 1160-1163, 2005

      32 Petersen, R. C., "Mild cognitive impairment : clinical characterization and outcome" 56 (56): 303-308, 1999

      33 Cutsuridis, V., "Microcircuits —Their structure, dynamics and role for brain function" 22 (22): 1037-1038, 2009

      34 Embree, L. M., "Memorial familiarity remains intact for pictures but not for words in patients with amnestic mild cognitive impairment" 50 (50): 2333-2340, 2012

      35 Swets, J. A., "Measuring the accuracy of diagnostic systems" 240 (240): 1285-, 1988

      36 Troyer, A. K., "Item and associative memory in amnestic mild cognitive impairme nt : performance on standardized memory tests" 22 (22): 10-16, 2008

      37 Hamalainen, A., "Increased fMRI responses during encoding in mild cognitive impairment" 28 (28): 1889-1903, 2007

      38 Rodríguez, J. J., "Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease" 3 (3): e2935-, 2008

      39 Postma, A., "How the brain remembers and forgets where things are : the neurocognition of object-location memory" 32 (32): 1339-1345, 2008

      40 de Rover, M., "Hippocampal dysfunction in patients with mild cognitiv e impairment : a functional neuroimaging study of a visuospatial paired associates lea rning task" 49 (49): 2060-2070, 2011

      41 Yassa, M. A., "High-resolution structural and functional MRI of hippocampal CA3 and dentate gyru s in patients with amnestic mild cognitive impairment" 51 (51): 1242-1252, 2010

      42 Travis, S. G., "High field structural MRI reveals specific episodic memory correlates in the subfields of the hippocampus" 53 : 233-245, 2014

      43 Han, S. D., "Hierarchical cognitive and psychosocial predictors of amnestic mild cognitive impair ment" 16 (16): 721-729, 2010

      44 Li, B., "Failure of neuronal maturation in Alzheimer disease dentate gyrus" 67 (67): 78-84, 2008

      45 Chua, E. F., "Evidence for a specific role of the anterior hippocampal region in successful associative encoding" 17 (17): 1071-1080, 2007

      46 Irish, M., "Everyday episodic memory in amnestic mild cognitive impairment : a preliminary investigation" 12 (12): 80-, 2011

      47 Morris, R. G., "Elements of a neurobiological theory of the hippocampus : the role of activity-dependent synaptic plasticity in memory" 358 (358): 773-786, 2003

      48 Tulving, E., "EPISODIC MEMORY : From Mind to Brain" 53 (53): 1-25, 2002

      49 Standish, T., "Do the ABCS 135 short cognitive screen and its subtests discriminate between normal cognition, mild cognitive impair ment and dementia" 22 (22): 189-194, 2007

      50 West, M. J., "Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease" 344 (344): 769-772, 1994

      51 Wang, P., "Differences in learning rates for item and associ ative memories between amnestic mild cognitive impairment and healthy controls" 9 (9): 29-, 2013

      52 Lee, J. H., "Development of the Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K) clinical and neuropsychological assessment batteries" 57 (57): P47-P53, 2002

      53 Papp, K. V., "Detecting Subtle Changes in Visuospatial Executive Function and Learning in the amnestic Va riant of Mild Cognitive Impairment" 6 (6): e21688-, 2011

      54 Millis, S. R., "Confirmatory factor anal ysis of the Wechsler Memory Scale-III" 21 (21): 87-93, 1999

      55 Marcopulos, B., "Cognitive impairment or inadequate norms? A study of healthy, rural, older adults with limited education" 11 (11): 111-131, 1997

      56 우종인, "CERAD-K : 치매 진단평가를 위한 한국판 CERAD 평가집 = the Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease Assessme nt Packet, the 1st Edition" 서울대학교 출판부 2003

      57 Benedict, R. H., "Brief visuospatial memory test--revised: professional manual"

      58 Kalaria, R. N., "Alzheimer's disea se and vascular dementia in developing countries : prevalence, management, and risk factors" 7 (7): 812-826, 2008

      59 Zhao, Shengjie, "A clinical memory battery for screening for amnestic mild cognitive impairment in an elderly chinese population" 18 (18): 774-779, 2011

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      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2022-06-27 학술지명변경 외국어명 : Locality and Globality: Korean Journal of Social Sciences -> Locality and Globality: International Journal of Social Sciences KCI등재
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2018-04-17 학술지명변경 한글명 : 사회과학연구 -> 지역과 세계
      외국어명 : 미등록 -> Locality and Globality: Korean Journal of Social Sciences
      KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2014-01-01 평가 등재학술지 선정 (계속평가) KCI등재
      2013-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2012-01-01 평가 등재후보학술지 유지 (기타) KCI등재후보
      2010-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.68 0.68 0.64
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.62 0.66 0.95 0.08
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