홍삼추출물 투여 후 Paraquat가 투여된 생쥐간에서 Glutathione과 Lipid Peroxidation에 미치는 항산화 효과 = Antioxidative Effects of Korean Red Ginseng Extracts on the Glutathione and Lipid Peroxidation in the Liver of Mouse Treated with Paraquat

국문 초록 (Abstract)

본 연구결과에서 볼 때 paraquat 독성 생존율 실험에서는 ascorbic acid가 우수하였고, 간 조직 내 과산화수소 (H₂O₂) 축적해소는 알콜추출물에서 우수하였으며, GPx 활성도 수준은 홍삼지용성추출물과 ascorbic acid에서 우수하였다. 한편 GSH량은 증가되면서 GSSG량이 감소되는 glutathion 환원반응이 우수한 것은 ascorbic acid에서만이 확인되었다. 한편 생체 내 MDA량 감소는 홍삼수용성 추출물과 ascorbic acid에서만 우수한 효능을 발휘하였다. 이 같은 실험결과들로 미루어 볼 때 ascorbic acid가 항산화 효능이 있는 것은 본 실험에서도 입증되고 있으며, 아울러 홍삼에서도 추출물마다 독특한 항산화 효능이 나타나고 있다.

다국어 초록 (Multilingual Abstract)

The anti-oxidative effects of Korean red ginseng extracts (total saponine, water extracts, alcohol extracts, lipophilic extracts), which were administered with the concentration of 200 ㎎/㎏ BW, were investigated after the injection of paraquat (1,1-dimethy1-4,4-bipyrimidinium dichloride: PQ) with dosage of 100 ㎎/㎏ BW on the peritoneal cavity to 6 weeks of 23~26 gm ICR male mice. The accumulation of hydrogen peroxide (H₂O₂) on the liver of mouse was lowered only in alcohol extract-treated group (p＜0.05). The activity of glutathione peroxidase increased in the mouse treated with lipophilic ginseng extracts. And GSSG level was lowered in all groups, and this might be due to the paraquat ions that might prevent the reaction of GSSG into GSH. But we cannot find any relation between glutathione oxido-reductase activity on Korean ginseng extracts. Finally, the lipid peroxidation (MDA) level was lowest (p＜0.01) in the group of mouse treated with water extracts of ginseng.

목차 (Table of Contents)

• 국문초록
• 서론
• 재료 및 방법
• 결과
• 고찰
• 참고문헌
• =Abstract=