저자들은 경련을 일으킨 후 시행한 뇌 자기공명영상에서 광범위한 뇌백질의 변화가 발견된 알렉산더 병 환자를 관찰하여 문헌 고찰과 함께 보고하는 바이다. 이 환자는 로젠탄 섬유의 형성...
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https://www.riss.kr/link?id=A76618176
2009
-
516
KCI등재후보
학술저널
215-220(6쪽)
1
0
상세조회0
다운로드국문 초록 (Abstract)
저자들은 경련을 일으킨 후 시행한 뇌 자기공명영상에서 광범위한 뇌백질의 변화가 발견된 알렉산더 병 환자를 관찰하여 문헌 고찰과 함께 보고하는 바이다. 이 환자는 로젠탄 섬유의 형성...
저자들은 경련을 일으킨 후 시행한 뇌 자기공명영상에서 광범위한 뇌백질의 변화가 발견된 알렉산더 병 환자를 관찰하여 문헌 고찰과 함께 보고하는 바이다. 이 환자는 로젠탄 섬유의 형성에 관여하는 GFAP 유전자에 돌연변이가 있었고 이것은 알렉산더 병의 진단에 이용되었다. 첫 내원 당시 발달은 정상이었으나 3개월 후 시행한 발달 검사에서 퇴행하는 양상을 보였다. 환아는 항경련제로 경련을 조절하면서 신경운동치료 중으로 경과관찰이 필요하다.
다국어 초록 (Multilingual Abstract)
Alexander disease(AD) is a rare fatal demyelinating disorder, caused by the mutation of glial fibrillary acidic protein(GFAP) gene. It is characterized by progressive demyelination of central nervous system, and the accumulation of Rosenthal fibers wi...
Alexander disease(AD) is a rare fatal demyelinating disorder, caused by the mutation of glial fibrillary acidic protein(GFAP) gene. It is characterized by progressive demyelination of central nervous system, and the accumulation of Rosenthal fibers within astrocytes. It is divided into three group: infantile, juvenile, and adult. The infantile type is most common, has onset during the first 2 years of life. It shows macrocephaly and psychomotor delay, spastic paraparesis, seizure, and feeding problems, and usually dies within the first decade. The severity of the pathological changes depend on the age of onset. Radiological study revealed white matter loss, usually with frontal predominance. It is diagnosed by DNA analysis. We present case of a 10-month-old male patient with AD. He had focal seizures, demyelination in the frontal lobe in MRI, and the presence of a K86E mutaion in the GFAP gene, involving the replacement of adenosine with guanine.
참고문헌 (Reference)
1 Johnson AB., "Rosenthal fibers in Alexander's disease show glial fibrillary acidic protein (GFAP) immunoreactivity with the immunogold staining method" 45 : 349-, 1986
2 Alexander WS., "Progressive fibrinoid degeneration of fibrillary astrocytes associated with mental retardation in a hydrocephalic infant" 72 : 373-381, 1949
3 Bobele GB., "Neuroimaging findings in Alexander's disease" 5 : 253-258, 1990
4 Brenner M., "Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease" 27 : 117-120, 2001
5 Gorospe JR., "Molecular findings in symptomatic and pre-symptomatic Alexander disease patients" 58 : 1451-1453, 2002
6 Valk J., "Magnetic resonancer of myelin, myelination, and myelin disoders in :Alexander's disease" 165-172, 1989
7 Goldman JE., "Isolation of a major protein component of Rosenthal fibers" 130 : 569-578, 1988
8 Li R., "GFAP mutations in Alexander disease" 20 : 259-268, 2002
9 Duckett S., "Biopsy diagnosis of familial Alexander's disease" 18 : 134-138, 1992
10 Probst EN., "Atypical focal MRI lesions in a case of juvenile Alexander's disease" 53 : 118-120, 2003
1 Johnson AB., "Rosenthal fibers in Alexander's disease show glial fibrillary acidic protein (GFAP) immunoreactivity with the immunogold staining method" 45 : 349-, 1986
2 Alexander WS., "Progressive fibrinoid degeneration of fibrillary astrocytes associated with mental retardation in a hydrocephalic infant" 72 : 373-381, 1949
3 Bobele GB., "Neuroimaging findings in Alexander's disease" 5 : 253-258, 1990
4 Brenner M., "Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease" 27 : 117-120, 2001
5 Gorospe JR., "Molecular findings in symptomatic and pre-symptomatic Alexander disease patients" 58 : 1451-1453, 2002
6 Valk J., "Magnetic resonancer of myelin, myelination, and myelin disoders in :Alexander's disease" 165-172, 1989
7 Goldman JE., "Isolation of a major protein component of Rosenthal fibers" 130 : 569-578, 1988
8 Li R., "GFAP mutations in Alexander disease" 20 : 259-268, 2002
9 Duckett S., "Biopsy diagnosis of familial Alexander's disease" 18 : 134-138, 1992
10 Probst EN., "Atypical focal MRI lesions in a case of juvenile Alexander's disease" 53 : 118-120, 2003
11 Staba MJ., "Allogenic bone marrow transplantation for Alexander's disease" 20 : 247-248, 1997
12 Schuster V., "Alexander's disease: crainal MRI and ultrasound findings" 21 : 133-134, 1991
13 Pridmore CL., "Alexander's disease: clues to diagnosis" 8 : 133-144, 1993
14 Russo LS., "Alexander's disease. A report and reappraisal" 26 : 607-614, 1976
15 Messing A., "Alexander disease: new insights from genetics" 60 : 563-573, 2001
16 van der Knaap MS., "Alexander disease: diagnosis with MR imaging" 3 : 541-552, 2001
17 Reichard EAP., "Alexander disease: a case report and review of the literature" 16 : 327-343, 1996
18 Johnson AB., "Alexander disease: A leukodystrophy caused by a mutation in GFAP" 5 : 961-964, 2004
장바이러스 수막염 유행 시 뇌척수액 검사의 임상적 고려 사항에 관한 연구
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2019 | 평가예정 | 신규평가 신청대상 (신규평가) | |
2018-12-01 | 평가 | 등재후보 탈락 (계속평가) | |
2016-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | |
2012-01-01 | 평가 | 등재후보 탈락 (등재후보1차) | |
2010-01-01 | 평가 | 등재후보 1차 FAIL (등재후보1차) | |
2008-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.17 | 0.17 | 0.17 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.16 | 0.14 | 0.384 | 0.02 |