본 연구에서는 미네랄이 함유된 해양심층수(DSW)가 신장 기능에 미치는 항산화 효과를 세포 모델을 사용하여 확인하였다. DSW 샘플은 최적의 칼슘/마그네슘 비율을 결정하기 위한 목적으로, ...
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https://www.riss.kr/link?id=A107774069
2021
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Antioxidation ; Calcium ; Deep sea water ; Human embryonic kidney cells ; Magnesium ; Reactive oxygen species ; 마그네슘 ; 신장세포 ; 칼슘 ; 항산화 ; 해양심층수 ; 활성산소종
KCI등재,SCOPUS
학술저널
165-170(6쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
본 연구에서는 미네랄이 함유된 해양심층수(DSW)가 신장 기능에 미치는 항산화 효과를 세포 모델을 사용하여 확인하였다. DSW 샘플은 최적의 칼슘/마그네슘 비율을 결정하기 위한 목적으로, ...
본 연구에서는 미네랄이 함유된 해양심층수(DSW)가 신장 기능에 미치는 항산화 효과를 세포 모델을 사용하여 확인하였다. DSW 샘플은 최적의 칼슘/마그네슘 비율을 결정하기 위한 목적으로, 각기 다른 칼슘 및 마그네슘 비율을 가진 4가지 샘플-미량 미네랄(TM), 고 마그네슘(HM), 고 마그네슘 저염(HMLS) 및 고 마그네슘 고 칼슘(HMHC)-로 준비되었다. 신장 세포주 HEK293를 2시간 동안 NaCl로 처리하여 ROS를 유도한 후, 마그네슘과 칼슘 등의 미네랄이 서로 다른 비율로 용해된 물로 처리하여 ROS 농도와 항산화 효소 활성 및 단백질을 측정하였다. 물 샘플 중 HMLS는 ROS에 대한 세포에 가장 많은 보호 효과를 나타냈다. 세포 내 글루타티온 함량은 HMLS 그룹과 HMHC 그룹에서 가장 높았다. 반면, TM과 HMHC는 항산화 유전자의 mRNA 발현에서 대조군과 유사한 경향을 보였다. 이러한 결과는 DSW가 과도한 나트륨 섭취로 인한 신장의 산화 스트레스를 예방하는 데 도움이 될 수 있음을 시사한다. 또한 ROS 농도와 항산화 마커 측정 결과를 종합하여 볼 때 HMLS 와 HMHC가 신장 세포 모델에서 우수한 항산화 효과를 가진 DSW 샘플이라고 판단할 수 있다.
다국어 초록 (Multilingual Abstract)
In this study, the antioxidant effects of mineral-containing deep sea water (DSW) on kidney function was confirmed using a cell model. DSW samples were prepared with different mineral concentrations including calcium and magnesium―the main minerals ...
In this study, the antioxidant effects of mineral-containing deep sea water (DSW) on kidney function was confirmed using a cell model. DSW samples were prepared with different mineral concentrations including calcium and magnesium―the main minerals found in DSW―to derive the following sample groups: trace minerals (TM), high magnesium (HM), high magnesium, low salt (HMLS) and high magnesium, high calcium (HMHC). The purpose of this preparation was to determine the optimal calcium/magnesium ratio in DSW. Human embryonic kidney (HEK293) cells were exposed to sodium chloride (NaCl) for 2 h to induce release of reactive oxygen species (ROS). Thereafter, the cells were treated with the respective DSW samples before ROS concentrations, as well as antioxidant enzyme activity and protein levels, were measured. Among the water samples, HMLS showed the most protective effect against ROS, whereas the intracellular glutathione content was highest in cells from the HMLS- and HMHC-treated groups. However, TM-and HMHC-treated cells showed similar tendencies to the control group, in terms of mRNA expression of antioxidant genes. These results suggested that DSW may aid in preventing renal oxidative stress caused by excessive sodium intake. Furthermore, it was determined that HMLS and HMHC water samples displayed good antioxidant effects in the kidney cell model, based on the combined results of ROS concentration and antioxidant marker measurements.
참고문헌 (Reference)
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1 McDowell LR, "Vitamins and minerals functioning as antioxidants with supplementation considerations" 30-31, 2007
2 Rebecca J Suckling, "The health impacts of dietary sodium and a low-salt diet" Royal College of Physicians 15 (15): 585-588, 2015
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4 Andrea Rosanoff, "Suboptimal magnesium status in the United States: are the health consequences underestimated?" Oxford University Press (OUP) 70 (70): 153-164, 2012
5 Alton Meister, "Selective Modification of Glutathione Metabolism" American Association for the Advancement of Science (AAAS) 220 (220): 472-477, 1983
6 Francesco P Cappuccio, "Salt and cardiovascular disease" BMJ 334 (334): 859-860, 2007
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9 Shan Chen, "Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury" Hindawi Limited 2013 : 1-7, 2013
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상업용 올리브 잎 추출물의 화합물 특성과 이들의 oleuropein 함량 비교분석
연잎(Nelumbo nucifera) 추출물의 in vitro 생리활성
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-05-09 | 학술지명변경 | 한글명 : Agricultrual Chemistry and Biotechnology -> Journal of Applied Biological Chemistry외국어명 : 미등록 -> Journal of Applied Biological Chemistry | |
2006-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2003-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2002-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2000-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.41 | 0.41 | 0.39 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.4 | 0.44 | 0.741 | 0.16 |