Somatostatin ( SMS 201 - 995 ) 이 흰쥐의 위액과 위점막 당단백질에 미치는 영향 = The Effect of Somatostatin ( SMS 201 - 995 ) toGlycoprotein of Gastric Juice and Mucus in RatsSomatostatin ( SMS 201 - 995 ) 이 흰쥐의 위액과 위점막 당단백질에 미치는 영향

다국어 초록 (Multilingual Abstract)

Somatostatin, a peptide present in hypothalamus, gastric mucosa, and pancreas suppress several gastrointestinal functions. Its short half life of two or three minutes prevents its clinical use. According to the report that subcutaneous administration of the synthetic SMS analogue SMS 201-995 produced a marked inhibition of pentagastrin-stimulated acid secretion, we have therefre evaluated the effect of SMS 201-995 to glycoprotein of gastric juice and mucus in rats. The results obtained were as follows. 1) Somatostatin increased sialic acid concentration in gastric juice and mucus significantly. 2) When somatostatin and indomethacin were given, the sialic acid concentration was lower compared with somatostatin given alone in gastric juice. 3) The sialic acid concentration after indomethacin alone was not significantly different from the control in gastric juice and soluble mucus.