유방암종에서 p53, cyclin D1 및 cathersin D 단백발현의 의의 = Significance of expression of p53, cyclin D1 and cathepsin D in breast carcinoma

다국어 초록 (Multilingual Abstract)

Background and Objectives: Breast carcinoma is a heterogenous disease. The prognosis of this carcinoma correlates with various prognostic factors. The aim of this study was to assess the prognostic significance of expression of p53, cyclin Dl and cathepsin D protiens in association with various prognostic factors in invasive breast carcinoma. Materials and Methods: The relationship is presented between expression of p53, cyclin D1 and cathepsin D by immunohistochemistry and various established prognostic factors such as tumor size, histologic grade, lymph node status and extensive intraductal component in 55 cases of invasive breast carcinoma. Results: No significant correlations were observed between expression of p53, cyclin Dl and cathepsin D and tumor size. The expression of p53 correlated with high histologic grade. The expression of p53 and cyclin Dl correlated with lymph node metastasis. Conclusion: These results indicate that expression of p53 and cyclin Dl in invasive ductal carcinoma may be an important prognostic factor, closely related to the high histologic grade and lymph node metastasis.

목차 (Table of Contents)

• 서론
• 재료 및 방법
• 1. 연구재료
• 2. 연구방법
• 1) 형태학적 소견
• 2) 면역조직화학적 방법
• 3) 염색 결과판독
• 4) 통계처리
• 결과
• 1. p53, cyclin D1 및 cathepsin 단백 발현(Tabte 1)
• 2. 종양의 크기에 따른 p53, cyclin D1 및 cathepsin D 단백 발현 (Table 2)
• 3. 조직학적 분화도에 따른 p53, cyclin D1 및 cathepsin 단백 발현 (Table 2)
• 4. 림프절 전이에 따른 p53, cyclin D1 및 cathepsin 단백 발현 (Table 2)
• 5. ElC와 림프절 전이와의 관계 (Table 3)
• 고찰
• 결론