β2-아드레날린성 수용체 유전자 다형성이원발성 고혈압에 미치는 영향 = The Effects of the β2-Adrenergic Receptor Gene Polymorphism on theRisk of Essential Hypertension

다국어 초록 (Multilingual Abstract)

Background and Objectives：Considering the physiological importance of the β2-adrenergic receptor (ADRB2)gene, “functional” molecular variations of the gene might cause attenuated vasodilatation, leading to increased totalperipheral resistance and; hence, ultimately result in hypertension. Significant evidence has been provided for thepathophysiological involvement of the β2-adrenergic receptor (ADRB2) in hypertension. The genetic variationof the ADRB2 gene, to see if there might be any relationship to essential hypertension, was investigated. Subjectsand Methods：One ADRB2 gene polymorphism, Arg16Gly (Arg→Gly variant), was investigated in this study.The genotypes of Arg16Gly in 318 hypertensive patients and 309 normotensive subjects were analyzed. Results：No significant differences were found in the allele and genotype frequencies between patients with hypertensionand normotensive subjects. There was no association of the ADRB2 polymorphism (Arg16Gly) with hypertensionor the other phenotypes measured in our study populations. Conclusion：Our data suggest that ADRB2 Arg16Glypolymorphisms are unlikely to confer the genetic susceptibility for hypertension in the Korean population. However,further investigation is warranted to clarify the relevance of ADRB2 polymorphisms in blood pressure regulation

국문 초록 (Abstract)

배경 및 목적：교감신경계는 소디움 평형, 말초혈관의 저항, 심박출량을변화시킴으로써 혈압을 조절하는데, β2-아드레날린성 수용체(beta 2 adrenergic receptor, ADRB2) 촉진제는 세포내c-AMP 농도를 증가시켜 혈관 이완을 유발하고, 신장에서소디움의 배설과 레닌의 분비를 통해 혈압을 조절한다. 저자들은 한국인에 있어서 ADRB2 유전자 다형성이 원발성 고혈압에 미치는 영향에 대해 알아보고자 하였다.방 법：본 연구에서는 고혈압이 있는 환자군 318명과 정상 혈압을 갖는 대조군 309명을 대상으로 유전형 분석을 통하여ADRB2 유전자 다형성 중 Arg16Gly 변이와 고혈압의 연관관계를 분석하였다.결 과：고혈압군에서 평균 연령이 높았으며, 체질량지수(BMI), 허리와 엉덩이 둘레비, 혈중 총 콜레스테롤, 중성지방, 저밀도 지단백 콜레스테롤, 고밀도 지단백 콜레스테롤 수치가 대조군과 비교하여 유의한 차이를 보였다. 유전형 분석 결과 고혈압군과 대조군 사이에 ADRB2 유전자형의 분포에는 차이가 없었다.
결 론：한국인에서 ADRB2 Arg16Gly 변이형은 고혈압과 상관관계가 없었다. 그러나 ADRB2 유전자와 고혈압의 상관관계를 분석하기 위해서는 ADRB2 유전자내 존재하는 다른 유전자
변이에 대한 연구가 시행되어져야 할 것으로 사료된다.

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