Laboratory animal medicine

목차 (Table of Contents)

• CONTENTS
• List of Reviewers = xi
• List of Contributors = xiii
• Preface to the Third Edition = xvii
• 1. Laboratory Animal Medicine : Historical Perspectives / JAMES G. FOX ; B. TAYLOR BENNETT
• Ⅰ. Introduction = 1
• Ⅱ. Origins of Animal Experimentation = 2
• Ⅲ. Early Veterinarians in Laboratory Animal Science and Medicine = 5
• Ⅳ. The Organizations of Laboratory Animal science = 10
• Ⅴ. Education and Training in Laboratory Animal Medicine = 17
• Ⅵ. ACLAM-Sponsored Texts = 18
• Ⅶ. Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine = 19
• Ⅷ. Regulation of Animal Research in the United Kingdom and Canada = 19
• Ⅸ. Commercial and Academic Breeding of Rodents = 20
• Ⅹ. Conclusion = 20
• Acknowledgment = 20
• References = 20
• 2. Laws, Regulations, and Policies Affecting the Use of Laboratory Animals / KATHRYN A.L. BAYNE ; LYNN C. ANDERSON
• Ⅰ. Introduction = 23
• Ⅱ. Animal Welfare = 24
• Ⅲ. Importation and Exportation of Animals and Animal Products = 36
• Ⅳ. Hazardous Substances = 40
• Ⅴ. Nucleic Acid and Nanomaterial Research Guidelines = 41
• References = 41
• 3. Biology and Diseases of Mice / MARK T. WHARY ; NICOLE BAUMGARTH ; JAMES G. FOX ; STEPHEN W. BARTHOLD
• Ⅰ. Introduction = 43
• Ⅱ. Biology = 57
• Ⅲ. Diseases = 73
• References = 137
• 4. Biology and Diseases of Rats / GLEN M. OTTO ; CRAIG L. FRANKLIN ; CHARLES B. CLIFFORD
• Ⅰ. Introduction = 151
• Ⅱ. Biology = 153
• Ⅲ. Diseases = 166
• Acknowledgment = 196
• References = 196
• 5. Biology and Diseases of Hamsters / EMILY L. MIEDEL ; F. CLAIRE HANKENSON
• Ⅰ. Introduction = 209
• Ⅱ. Syrian Hamster = 209
• Ⅲ. Chinese Hamster = 229
• Ⅳ. Armenian Hamster = 233
• Ⅴ. European Hamster = 233
• Ⅵ. Djungarian Hamster = 235
• References = 237
• 6. Biology and Diseases of Guinea Pigs / NIRAH H. SHOMER ; HILDA HOLCOMBE ; JOHN E. HARKNESS
• Ⅰ. Introduction = 247
• Ⅱ. Biology = 249
• Ⅲ. Diseases = 255
• References = 277
• 7. Biology and Diseases of Other Rodents / THOMAS M. DONNELLY ; INGRID BERGIN ; MELANIE IHRIG
• Ⅰ. Introduction = 286
• Ⅱ. Ground Squirrels : Urocitellus, Ictodomys, and Spermophilus = 290
• Ⅲ. Prairie Dogs : Cynomys = 293
• Ⅳ. Pocket Gophers : Geomyidae = 297
• Ⅴ. Kangaroo Rats : Dipodomys = 299
• Ⅵ. Pack Rats : Neotoma = 301
• Ⅶ. Grasshopper Mice : Onychomys = 303
• Ⅷ. Deer Mice : Peromyscus = 306
• Ⅸ. Rice Rats : Oryzomys = 308
• Ⅹ. Cane Mice : Zygodontomys = 309
• Ⅺ. Cotton Rats : Sigmodon = 311
• Ⅻ. White-Tailed Rats : Mystromys = 313
• XIII. Gerbils and Jirds : Meriones = 315
• XIV. Voles : Microtus = 320
• XV. Multimammate Rats／Mice : Mastomys = 324
• XVI. Degus : Octodon = 326
• XVII. Naked Mole Rats : Heterocephalus Glaber = 328
• References = 330
• 8. The Laboratory Woodchuck(Marmota monax) / CHRISTINE A. BELLEZZA ; SANDRA SEXTON ; LESLIE I. CURTIN ; PATRICK W. CONCANNON ; BETTY H. BALDWIN ; LOU ANN GRAHAM ; WILLIAM E. HORNBUCKLE ; LOIS ROTH ; BUD C. TENNANT
• Ⅰ. Introduction = 352
• Ⅱ. Biology = 356
• Ⅲ. Diseases = 364
• Ⅳ. The Woodchuck as an Experimental Animal Model for HBV Research = 372
• References = 380
• 9. Biology and Diseases of Chinchillas / CHARLIE C. HSU ; MAIA M. CHAN ; COLETTE L. WHELER
• Ⅰ. Introduction = 387
• Ⅱ. Biology = 389
• Ⅲ. Diseases = 392
• References = 405
• 10. Biology and Diseases of Rabbits / MEGAN H. NOWLAND ; DAVID W. BRAMMER ; ALEXIS GARCIA ; HOWARD G. RUSH
• Ⅰ. Introduction = 411
• Ⅱ. Biology = 415
• Ⅲ. Diseases = 421
• References = 450
• 11. Microbiological Quality Control for Laboratory Rodents and Lagomorphs / WILLIAM R. SHEK ; ABIGAIL L. SMITH ; KATHLEEN R. PRITCHETT-CORNING
• Ⅰ. Introduction = 463
• Ⅱ. Microbiological Quality Specifications = 465
• Ⅲ. Biosecurity = 467
• Ⅳ. Health Monitoring = 476
• Ⅴ. Outbreak Management and Investigation = 496
• References = 499
• 12. Biology and Diseases of Dogs / JEAN A. NEMZEK ; PATRICK A. LESTER ; A. MARISSA WOLFE ; ROBERT C. DYSKO ; DANIEL D. MYERS, JR.
• Ⅰ. Introduction = 511
• Ⅱ. Biology = 513
• Ⅲ. Diseases = 521
• Acknowledgments = 549
• References = 549
• 13. Biology and Diseases of Cats / TANYA BURKHOLDER ; CARMEN LEDESMA FELICIANO ; SUE VANDEWOUDE ; HENRY J. BAKER
• Ⅰ. Introduction = 555
• Ⅱ. Sources of Cats = 558
• Ⅲ. Housing = 560
• Ⅳ. Breeding Colony Management = 564
• Ⅴ. Nutrition and Feeding = 566
• Ⅵ. Infectious Disease Exclusion and Control = 567
• Acknowledgments = 572
• References = 572
• 14. Biology and Diseases of Ferrets / JOERG MAYER ; DR. ROBERT P. MARINI ; JAMES G. FOX
• Ⅰ. Introduction = 577
• Ⅱ. Biology = 580
• Ⅲ. Diseases = 587
• Acknowledgment = 616
• References = 616
• 15. Biology and Diseases of Ruminants(Sheep, Goats, and Cattle) / WENDY J. UNDERWOOD ; RUTH BLAUWIEKEL ; MARGARET L. DELANO ; ROSE GILLESBY ; SCOTT A. MISCHLER ; ADAM SCHOELL
• Ⅰ. Introduction = 623
• Ⅱ. Biology = 627
• Ⅲ. Diseases = 637
• References = 692
• 16. Biology and Diseases of Swine / KRISTI L. HELKE ; PAULA C. EZELL ; RAIMON DURAN-STRUUCK ; M. MICHAEL SWINDLE
• Ⅰ. Introduction = 695
• Ⅱ. Biology = 699
• Ⅲ. Diseases = 709
• Acronyms Used in Chapter = 755
• Acknowledgments = 756
• References = 756
• 17. Nonhuman Primates / ELIZABETH R. MAGDEN ; KEITH G. MANSFIELD ; JOE H. SIMMONS ; CHRISTIAN R. ABEE
• Ⅰ. Introduction = 772
• Ⅱ. Taxonomy = 773
• Ⅲ. Biology = 777
• Ⅳ. Principles of Colony Management = 822
• Ⅴ. Medical Management = 831
• Ⅵ. Diseases = 845
• Acknowledgments = 901
• References = 901
• 18. Biology and Diseases of Amphibians / DORCA P. O'ROURKE ; MATTHEW D. ROSENBAUM
• Ⅰ. Introduction = 931
• Ⅱ. Biology = 939
• Ⅲ. Diseases = 949
• References = 960
• 19. Biology and Diseases of Reptiles / DORCA P. O'ROURKE ; KVIN LERTPIRIYAPONG
• Ⅰ. Introduction = 967
• Ⅱ. Biology = 974
• Ⅲ. Diseases = 984
• References = 1005
• 20. The Biology and Management of the Zebrafish / MICHAEL Y. ESMAIL ; KEITH M. ASTROFSKY ; CHRISTIAN LAWRENCE ; FABRIZIO C. SERLUCA
• Ⅰ. Introduction = 1016
• Ⅱ. Zebrafish : The Experimental Model in Biomedical Research = 1017
• Ⅲ. Significances of Healthy Management in the Aquatic Animal Facility = 1022
• Ⅳ. Environmental Factors Important to Zebrafish Health = 1023
• Ⅴ. General Features of Laboratory Zebrafish Facilities = 1026
• Ⅵ. Nutrition and Feeding of Zebrafish = 1031
• Ⅶ. Pathogen Control Program = 1032
• Ⅷ. Techniques and Anesthesia = 1034
• Ⅸ. Significant Diseases of Laboratory Zebrafish = 1038
• Acknowledgment = 1057
• References = 1057
• 21. Biology and Management of Laboratory Fishes / MICHAEL K. STOSKOPF
• Ⅰ. Introduction = 1063
• Ⅱ. Facility Design = 1064
• Ⅲ. Management and Husbandry = 1072
• Ⅳ. Medical Protocols = 1073
• Ⅴ. Zoonotic Considerations = 1076
• Ⅵ. Diseases = 1078
• References = 1086
• 22. Japanese Quail as a Laboratory Animal Model / JANET BAER ; RUSTY LANSFORD ; KIMBERLY CHENG
• Ⅰ. Introduction = 1087
• Ⅱ. Biology = 1089
• Ⅲ. Laboratory Management and Husbandry = 1094
• Ⅳ. Breeding and Rearing Quail = 1097
• Ⅴ. Diseases／Welfare Concerns = 1100
• References = 1104
• 23. Zebra Finches in Biomedical Research / MARY M. PATTERSON ; MICHALE S. FEE
• Ⅰ. Introduction = 1109
• Ⅱ. History and Taxonomy = 1110
• Ⅲ. Research Uses = 1110
• Ⅳ. Biology = 1111
• Ⅴ. Laboratory Management and Husbandry = 1114
• Ⅵ. Diseases／Welfare Concerns = 1120
• References = 1130
• 24. Preanesthesia, Anesthesia, Analgesia, and Euthanasia / PAUL FLECKNELL ; JENNIFER L.S. LOFGREN ; MELISSA C. DYSON ; ROBERT R. MARINI ; M. MICHAEL SWINDLE ; RONALD P. WILSON
• Ⅰ. Introduction = 1136
• Ⅱ. Rodents = 1136
• Ⅲ. Rabbits = 1149
• Ⅳ. Ferrets = 1156
• Ⅴ. Swine = 1162
• Ⅵ. Small Ruminants = 1168
• Ⅶ. Nonhuman Primates = 1180
• References = 1187
• 25. Techniques of Experimentation / MICHAEL R. TALCOTT ; WALTER AKERS ; ROBERT P. MARINI
• Ⅰ. Introduction = 1202
• Ⅱ. Identification Methods = 1202
• Ⅲ. Blood Collection and Intravenous Injection = 1204
• Ⅳ. Vascular Cannulation = 1211
• Ⅴ. Intraperitoneal Injection = 1215
• Ⅵ. Subcutaneous, Intramuscular, and Intraosseous Injection = 1215
• Ⅶ. Digestive System = 1215
• Ⅷ. Urinary System Techniques = 1221
• Ⅸ. Respiratory System Techniques = 1223
• Ⅹ. Reproductive System = 1226
• Ⅺ. Cardiovascular Techniques = 1231
• Ⅻ. Endocrine System Techniques = 1233
• XIII. Orthopedic Procedures for Laboratory Animals = 1235
• XIV. Neurosurgical Techniques = 1235
• XV. Tumor Transplantation = 1242
• XVI. Imaging Techniques = 1244
• XVII. Radiotelemetry = 1245
• XVIII. Thymectomy = 1245
• Acknowledgments = 1246
• References = 1246
• 26. Gnotobiotics / TRENTON R. SCHOEB ; RICHARD J. RAHIJA
• Ⅰ. Introduction = 1263
• Ⅱ. Terminology = 1264
• Ⅲ. History = 1265
• Ⅳ. Characteristics of Gnotobiotes = 1265
• Ⅴ. Establishing a Gnotobiotic Facility = 1266
• Ⅵ. Operation = 1275
• Ⅶ. Derivation of Germfree Mice = 1286
• Ⅷ. Resources = 1289
• References = 1290
• 27. Working Safely with Experimental Animals Exposed to Biohazards / JAMES R. SWEARENGEN ; CALVIN B. CARPENTER
• Ⅰ. Introduction = 1297
• Ⅱ. Risk Assessment = 1298
• Ⅲ. Managing an Animal Biocontainment Program = 1299
• Ⅳ. Standard Practices = 1304
• Ⅴ. Veterinary Care = 1306
• Ⅵ. Other Considerations = 1307
• Ⅶ. Summary = 1310
• References = 1311
• 28. Selected Zoonoses / JAMES G. FOX ; GLEN OTTO ; LESLEY A. COLBY
• Ⅰ. Introduction = 1313
• Ⅱ. Viral Diseases = 1314
• Ⅲ. Rickettsial Diseases = 1334
• Ⅳ. Chlamydial Infections = 1336
• Ⅴ. Bacterial Diseases = 1337
• Ⅵ. Fungal Diseases = 1350
• Ⅶ. Protozoal Diseases = 1351
• Ⅷ. Helminth Infections = 1356
• Ⅸ. Arthropod Infestations = 1356
• Acknowledgments = 1360
• References = 1360
• 29. Xenozoonoses : The Risk of Infection after Xenotransplantation / MARIAN G. MICHAELS
• Ⅰ. Introduction = 1371
• Ⅱ. Lessons from Allotransplantation／Historical Perspective = 1372
• Ⅲ. Potential Mechanisms for Cross-Species Infections = 1373
• Ⅳ. NonViral Agents = 1375
• Ⅴ. Development of SPF Herds = 1375
• Ⅵ. Potential Benefits of Xenotransplantation and Other Infectious Disease Issues = 1376
• Ⅶ. Issues after Xenotransplantation = 1377
• References = 1377
• 30. Occupational Health of Laboratory Animal Workers / PETER M. RABINOWITZ ; RAFAEL Y. LEFKOWITZ ; LISA A. CONTI ; CARRIE A. REDLICH ; BENJAMIN J. WEIGLER
• Ⅰ. Introduction = 1382
• Ⅱ. Occupational Illness and Injury in Laboratory Animal Workers = 1382
• Ⅲ. Occupational Health Approach = 1384
• Ⅳ. Hazard Identification = 1386
• Ⅴ. Hazard Controls = 1389
• Ⅵ. Occupational Medicine Services = 1392
• Appendix 30.1 = 1397
• Appendix 30.2 = 1399
• References = 1401
• 31. Genetic Monitoring of Laboratory Mice and Rats / MARJORIE C. STROBEL ; LAURA G. REINHOLDT ; RACHEL D. MALCOLM ; KATHLEEN PRITCHETT-CORNING
• Ⅰ. Introduction = 1403
• Ⅱ. History of Genetic Monitoring = 1404
• Ⅲ. Rodent Strains : Genetic Homogeneity or Genetic Diversity = 1407
• Ⅳ. SNP Analysis : Testing Strain Background = 1408
• Ⅴ. Allele-Specific Genotyping : Testing Mutant Strains = 1408
• Ⅵ. Maintaining Strains = 1409
• Ⅶ. Phenotype Quality Control = 1412
• Ⅷ. The Future of GQC = 1412
• Ⅸ. GQC : Practical Aspects = 1413
• Ⅹ. Conclusions = 1414
• References = 1414
• 32. Genetically Modified Animals / KATHLEEN R. PRITCHETT-CORNING ; CARLISLE P. LANDEL
• Ⅰ. Introduction = 1417
• Ⅱ. Manipulating Animals for Genetic Modification = 1418
• Ⅲ. Genetic Modification and Technologies = 1422
• Ⅳ. Colony Management for GM Mice and Rats = 1427
• Ⅴ. Finding Mouse and Rat Resources = 1437
• References = 1437
• 33. Factors That Can Influence Animal Research / DAVID G. BAKER ; NEIL S. LIPMAN
• Ⅰ. Introduction = 1441
• Ⅱ. Intrinsic Considerations = 1442
• Ⅲ. Extrinsic Considerations = 1444
• References = 1470
• 34. Animal Models in Biomedical Research / KIRK J. MAURER ; FRED W. QUIMBY
• Ⅰ. Introduction = 1497
• Ⅱ. What is an Animal Model? = 1497
• Ⅲ. Nature of Research = 1502
• Ⅳ. History of Animal Use in Biomedical Research = 1505
• References = 1526
• 35. Research in Laboratory Animal and Comparative Medicine / J. MARK CLINE ; THOMAS B. CLARKSON
• Ⅰ. Introduction = 1535
• Ⅱ. Principles of Experimentation = 1536
• Ⅲ. Role of the Laboratory Animal Specialist in Research = 1537
• Ⅳ. Research Training = 1539
• Ⅴ. Summary = 1540
• Acknowledgment = 1540
• References = 1540
• 36. Design and Management of Research Facilities / NEIL S. LIPMAN ; STEVEN L. LEARY
• Ⅰ. Introduction = 1543
• Ⅱ. Facility Planning and Design = 1544
• Ⅲ. Environmental Control and Monitoring = 1564
• Ⅳ. Housing and Equipment = 1570
• Ⅴ. Materials = 1577
• Ⅵ. Operational Issues = 1585
• Ⅶ. Conclusions = 1590
• References = 1591
• 37. Program Management / STEVEN M. NIEMI
• Ⅰ. Introduction and Definitions = 1599
• Ⅱ. Mission and Strategy : Where it All Starts = 1600
• Ⅲ. Managing People = 1601
• Ⅳ. Managing Money = 1605
• Ⅴ. Managing Operations = 1608
• Ⅵ. Concluding Remarks = 1612
• Appendix 1. Executive Summary of the 14 Toyota Way Principles = 1612
• References = 1614
• 38. Laboratory Animal Behavior / KATHRYN A.L. BAYNE ; BONNIE V. BEAVER ; JOY A. MENCH ; CHRISTINA WINNICKER
• Ⅰ. Introduction = 1617
• Ⅱ. Rodents = 1619
• Ⅲ. Rabbits = 1626
• Ⅳ. Laboratory Dogs and Cats = 1628
• Ⅴ. Nonhuman Primates = 1630
• Ⅵ. Farm Animals = 1636
• Ⅶ. Conclusions = 1641
• References = 1641
• 39. Animal Welfare / MARILYN J. BROWN ; CHRISTINA WINNICKER
• Ⅰ. Introduction = 1653
• Ⅱ. Animal Welfare as a Key Component in Research, Teaching, and Testing Using Animals = 1654
• Ⅲ. Animal Welfare - A Historical and Philosophical Perspective = 1655
• Ⅳ. Guidelines and Principles = 1656
• Ⅴ. Strategies to Optimize Animal Welfare = 1660
• Ⅵ. Examples of Challenging Research and Opportunities for Animal Welfare Optimization = 1664
• Ⅶ. Science of Animal Welfare = 1666
• Ⅷ. Conclusion and Summary = 1669
• References = 1669
• Index = 1673