Inhibitory Effects of 2-(4-Chlorophenyl)-1,3-selenazol-4-one on Lipopolysaccharide-induced Nitric Oxide Production in RAW 264.7 Cells

다국어 초록 (Multilingual Abstract)

In this study, the inhibitory effects of selenium-containing heterocyclic compound, selenazol derivatives on LPS-induced nitric oxide production in macrophage cells (RAW 264.7) were assessed. Five kinds of selenazol derivatives were shown to exhibit $5.4{\sim}41.7%$ of inhibitory effects at $10{\mu}M$. Among them, 2-(4-chlorophenyl)-1,3-selenazol-4-one generally evidenced a high degree of inhibitory activity with $IC_{50}=11.8{\mu}M$, and this compound also profoundly suppressed iNOS expression in LPS-treated RAW 264.7 cells. These results indicated that 2-(4-chlorophenyl)-1,3-selenazol-4-one might function as an anti-inflammatory agent via the inhibition of iNOS-mediated nitric oxide production.