Bcl-2 and other Inhibitors of Apoptosis : Mechanisms of Action

다국어 초록 (Multilingual Abstract)

Inhibition of programmed cell death and apoptosis represents a major step in the pathogenesis of most cancers, promoting clonal expasion of neoplastic cells, evasion of immune responses, and resistance to chemo- and radiotherapy. The suppression of cell death pathways can be achieved by alterations in the expression or function of apoptosis-regulating proteins that act in the prosimal, intermediate, or distal portions of the pathway. Examples of each of these will be discussed, including suppression of Fas/CD95-induced death by the Fas-binding protein FAP-1 (proximal), interference with mitochondria-dependent steps of cell death by Bcl-2 (intermediate), and direct suppression of caspases by IAP-family proteins (distal).