승마 에탄올 추출물의 진정 효과 = The Sedative Effects of Ethanol Extract from Cimicifugae Rhizoma

다국어 초록 (Multilingual Abstract)

The aim of this study is to evaluate the sedative effects of ethanol extract and the three major constituents of Cimicifugae Rhizoma. They decreased locomotor activity significantly, and enhanced sleeping duration induced by thiopental sodium. The ethanol extract of Cimicifugae rhizoma and 24-epi-7,8-didehydrocimigenol-3-xyloside (24-epi.) increased the Cl- influx into the intracellular area of SH-SY5Y neuroblastoma cells significantly. The present results demonstrate that the sedative effects of Cimicifugae rhizoma are mediated via the GABA-gated Cl- channel, partly by 24-epi.

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