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      KCI등재 SCOPUS

      Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes

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      https://www.riss.kr/link?id=A105948223

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      Study Design: A prospective genetic association study. Purpose: The etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated. However, studies with a larger patient subset are lacking,...

      Study Design: A prospective genetic association study.
      Purpose: The etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated.
      However, studies with a larger patient subset are lacking, and candidate genes involved in other disc degeneration phenotypes have not been evaluated. We studied the prevalence of MCs and genetic association of 41 candidate genes in a large Indian cohort.
      Overview of Literature: MCs are vertebral endplate signal changes predominantly observed in the lumbar spine. A significant association between MCs and lumbar disc degeneration and nonspecific low back pain has been described, with the etiopathogenesis implicating various mechanical, infective, and biochemical factors.
      Methods: We studied 809 patients using 1.5-T magnetic resonance imaging to determine the prevalence, patterns, distribution, and type of lumbar MCs. Genetic association analysis of 71 single nucleotide polymorphisms (SNPs) of 41 candidate genes was performed based on the presence or absence of MCs. SNPs were genotyped using the Sequenome platform, and an association test was performed using PLINK software.
      Results: The mean age of the study population (n=809) was 36.7±10.8 years. Based on the presence of MCs, the cohort was divided into 702 controls and 107 cases (prevalence, 13%). MCs were more commonly present in the lower (149/251, 59.4%) than in the upper (102/251, 40.6%) endplates. L4–5 endplates were the most commonly affected levels (30.7%). Type 2 MCs were the most commonly observed pattern (n=206, 82%). The rs2228570 SNP of VDR (p =0.02) and rs17099008 SNP of MMP20 (p =0.03) were significantly associated with MCs.
      Conclusions: Genetic polymorphisms of SNPs of VDR and MMP20 were significantly associated with MCs. Understanding the etiopathogenetic mechanisms of MCs is important for planning preventive and therapeutic strategies.

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      참고문헌 (Reference)

      1 Maatta JH, "Vertebral endplate change as a feature of intervertebral disc degeneration: a heritability study" 23 : 1856-1862, 2014

      2 Ohtori S, "Tumor necrosis factorimmunoreactive cells and PGP 9.5-immunoreactive nerve fibers in vertebral endplates of patients with discogenic low back pain and Modic Type 1 or Type 2 changes on MRI" 31 : 1026-1031, 2006

      3 Kawaguchi Y, "The association of lumbar disc disease with vitamin-D receptor gene polymorphism" 84 : 2022-2028, 2002

      4 Rajasekaran S, "Phenotype variations affect genetic association studies of degenerative disc disease: conclusions of analysis of genetic association of 58 single nucleotide polymorphisms with highly specific phenotypes for disc degeneration in 332 subjects" 13 : 1309-1320, 2013

      5 Albert HB, "Modic changes, possible causes and relation to low back pain" 70 : 361-368, 2008

      6 Kuisma M, "Modic changes in endplates of lumbar vertebral bodies: prevalence and association with low back and sciatic pain among middle-aged male workers" 32 : 1116-1122, 2007

      7 Albert HB, "Modic changes following lumbar disc herniation" 16 : 977-982, 2007

      8 Kjaer P, "Modic changes and their associations with clinical findings" 15 : 1312-1319, 2006

      9 de Roos A, "MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease" 149 : 531-534, 1987

      10 Schmid G, "Lumbar disk herniation: correlation of histologic findings with marrow signal intensity changes in vertebral endplates at MR imaging" 231 : 352-358, 2004

      1 Maatta JH, "Vertebral endplate change as a feature of intervertebral disc degeneration: a heritability study" 23 : 1856-1862, 2014

      2 Ohtori S, "Tumor necrosis factorimmunoreactive cells and PGP 9.5-immunoreactive nerve fibers in vertebral endplates of patients with discogenic low back pain and Modic Type 1 or Type 2 changes on MRI" 31 : 1026-1031, 2006

      3 Kawaguchi Y, "The association of lumbar disc disease with vitamin-D receptor gene polymorphism" 84 : 2022-2028, 2002

      4 Rajasekaran S, "Phenotype variations affect genetic association studies of degenerative disc disease: conclusions of analysis of genetic association of 58 single nucleotide polymorphisms with highly specific phenotypes for disc degeneration in 332 subjects" 13 : 1309-1320, 2013

      5 Albert HB, "Modic changes, possible causes and relation to low back pain" 70 : 361-368, 2008

      6 Kuisma M, "Modic changes in endplates of lumbar vertebral bodies: prevalence and association with low back and sciatic pain among middle-aged male workers" 32 : 1116-1122, 2007

      7 Albert HB, "Modic changes following lumbar disc herniation" 16 : 977-982, 2007

      8 Kjaer P, "Modic changes and their associations with clinical findings" 15 : 1312-1319, 2006

      9 de Roos A, "MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease" 149 : 531-534, 1987

      10 Schmid G, "Lumbar disk herniation: correlation of histologic findings with marrow signal intensity changes in vertebral endplates at MR imaging" 231 : 352-358, 2004

      11 Videman T, "Intragenic polymorphisms of the vitamin D receptor gene associated with intervertebral disc degeneration" 23 : 2477-2485, 1998

      12 Burke JG, "Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators" 84 : 196-201, 2002

      13 Modic MT, "Imagingof degenerative disk disease" 168 : 177-186, 1988

      14 Karppinen J, "Genetic factors are associated with modic changes in endplates of lumbar vertebral bodies" 33 : 1236-1241, 2008

      15 Chung CB, "End plate marrow changes in the asymptomatic lumbosacral spine: frequency, distribution and correlation with age and degenerative changes" 33 : 399-404, 2004

      16 Modic MT, "Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging" 166 (166): 193-199, 1988

      17 Cheung KM, "Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population" 31 : 1143-1148, 2006

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      연월일 이력구분 이력상세 등재구분
      2024 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2021-01-01 평가 등재학술지 선정 (해외등재 학술지 평가) KCI등재
      2020-12-01 평가 등재 탈락 (해외등재 학술지 평가)
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