Antihematotoxic Role of Bunium persicum Seed Differential Extracts in Animal Model: Reactive Oxygen Species Might Be a Contributor

다국어 초록 (Multilingual Abstract)

Objectives: Humans have been using plants as natural medicines since prehistoric times. Bunium persicum is a rich source of oils with different biological activities such as antioxidative and antimicrobial activities. The aim of this study is to evaluate the antihematotoxic and antioxidative effects of the differential extracts of B. persicum against leukemic blood induced hematotoxicity in an animal model.
Methods: This study was performed on animals, which were divided into several groups: normal control, disease control, and groups that were administered with differential extracts of plants. We measured the concentration of free radical [reactive oxygen species (ROS)] and hematological parameters as blast cells from the tibia and femur in different groups.
Results: The ROS level and blast cells count were higher in disease control groups than in groups treated with varying amounts of B. persicum extract and the normal group. Moreover, there was an imbalance in hematological parameters in untreated and treated groups with a correlation between free radicals and plant extract administration.
Conclusion: These findings may indicate a possible link between free radicals and hematotoxicity and blast cells, while depicting a potential therapeutic role for B. persicum against ROS-induced hematotoxicity.

참고문헌 (Reference)

1 Zangiabadi M, "Zataria multiflora and Bunium persicum essential oils as two natural antioxidants" 11 (11): 8-21, 2012

2 Koehn FE, "The evolving role of natural products in drug discovery" 4 (4): 206-220, 2005

3 Huggins CB, "Production and prevention of two distinctive kinds of destruction of adrenal cortex" 206 (206): 1310-1314, 1965

4 Sardari S, "Phytopharmaceuticals:Part 1. Antifungal activity of selected Iranian and Canadian plants" 36 (36): 180-188, 1998

5 Oroojalian F, "Phytochemical composition of the essential oils from three Apiaceae species and their antibacterial effects on food-borne pathogens" 120 (120): 765-770, 2010

6 Mochizuki T, "Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signalregulating kinase 1 pathway in pancreatic cancer PANC-1 cells" 25 (25): 3699-3707, 2006

7 Wube AA, "In vitro12(S )-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi" 102 (102): 191-196, 2005

8 Wan J, "In utero exposure to benzene increases embryonic c-Myb and Pim-1 protein levels in CD-1 mice" 228 (228): 326-333, 2008

9 Sher H, "Identification and conservation of important plant areas (IPAs) for the distribution of medicinal, aromatic and economic plants in the HindukusheHimalaya mountain range" 44 : 187-194, 2012

10 Hayashi I, "High-throughput spectrophotometric assay of reactive oxygen species in serum" 631 (631): 55-61, 2007

11 Sinenko SA, "Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model" 116 (116): 4612-4620, 2010

12 Tothova Z, "FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress" 128 (128): 325-339, 2007

13 Saha S, "Effect of methanolic leaf extract of Ocimum basilicum L. on benzeneinduced hematotoxicity in mice" 2012 : 176385-, 2012

14 Hole PS, "Do reactive oxygen species play a role in myeloid leukemias?" 117 (117): 5816-5826, 2011

15 Olson H, "Concordance of the toxicity of pharmaceuticals in humans and in animals" 32 (32): 56-67, 2000

16 Sharififar F, "Bioactivity of major components from the seeds of Bunium persicum (Boiss.) Fedtch" 23 (23): 300-304, 2010

17 Juntachote T, "Antioxidative properties and stability of ethanolic extracts of Holy basil and Galangal" 92 (92): 193-202, 2005

18 Gulcin I, "Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L)" 90 : 205-215, 2004

19 Kukic J, "Antioxidant activity of four endemic Stachys taxa" 29 (29): 725-729, 2006

20 Shahsavari N, "Antioxidant activity and chemical characterization of essential oil of Bunium persicum" 63 (63): 183-188, 2008

21 Panwar, "A low volume, high price crop for dry temperate hills" 25 : 21-23, 1992