Structure-Antimicrobial Activity Relationship of 4- or 5-Substituted 1-(2,6-Dichloro-4-trifluoromethylphenyl)-1H-1,2,3-triazole Analogues

다국어 초록 (Multilingual Abstract)

A series of 1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-1,2,3-triazole analogues have been tested for antimicrobial activity against thirteen bacteria and three fungi in order to observe the broad spectrum activity. Among the compounds tested, the C-4-chloropropyl derivative exhibited potent antibacterial and antifungal activities. The C-4-substituted regioisomers of 1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-1,2,3-triazole exhibited moderate selectivity to broad spectrum activity, compared to that of 5-substituted regioisomers.

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