주요 혈청형 구제역바이러스의 발생분포와 분자역학적 분석 = Geographical distribution and molecular epidemiology of the foot-and-mouth disease viruses of major groups

다국어 초록 (Multilingual Abstract)

Foot-and-mouth disease (FMD) virus exists in seven serotypes and is known to be a highly contagious disease that is hard to eradicate from the world. The O, A, Asia1 and SAT2 serotypes commonly infected cattle, sheep and goats during 2007~2009 throughout the world. In particular, the outbreak of the Asia1 serotype in China appeared in all areas from 2005 and is still present. Surprisingly, in 2009, Taiwan reported the first outbreak of the type O serotype since 2001. Then type A appeared in China for the first time since the early 1960s. The virus shows a close relationship to the viruses from Southeast Asia suggesting one or more recent introductions into China in the OIE reports. Recently the subtype of A/Iran05 spread to nearby countries exhibiting genomic evolution. The use of molecular epidemiology is an important tool in understanding and consequently controlling the FMD virus. The phylogenetic analysis with VP1 gene was especially useful for molecular epidemiological studies and showed the same pattern which matches with serotype classification. This paper describes basic information about the disease, and the serotype-specific characteristics and evolution to perform molecular epidemiological analysis. Furthermore, we show the importance of the genetic evolution on the FMD serotypes in global surveillance and molecular epidemiology of FMD for outbreak investigation.

참고문헌 (Reference)

1 박종현, "동아시아 유래 구제역바이러스 Asia1혈청형과 백신항원의 면역학적 상관성" 대한수의학회 49 (49): 221-229, 2009

2 Perez AM, "Variation in the VP1 gene of foot-and-mouth disease virus serotype A associated with epidemiological characteristics of outbreaks in the 2001 epizootic in Argentina" 20 (20): 433-439, 2008

3 Park JH, "Vaccination as a control measure during the outbreak of foot-and-mouth disease in 2000 in Korea" 119 : 63-70, 2004

4 Klein J, "Understanding the molecular epidemiology of foot-and-mouth-disease virus" 9 (9): 153-161, 2009

5 Klein J, "The molecular epidemiology of foot-and-mouth disease virus serotypes A and O from 1998 to 2004 in Turkey" 2 : 35-, 2006

6 Bastos AD, "The implications of virus diversity within the SAT 2 serotype for control of foot-andmouth disease in sub-Saharan Africa" 84 (84): 1595-1606, 2003

7 Park JH, "Surveillance of foot-and-mouthdisease in Korea" 33 (33): 153-163, 2009

8 Mohapatra JK, "Sequence variability in the structural protein-encoding region of foot-and-mouth disease virus serotype Asia1 field isolates" 77 (77): 153-161, 2004

9 Biswas S, "Sequence analysis of the non-structural 3A and 3C proteincoding regions of foot-and-mouth disease virus serotype Asia1 field isolates from an endemic country" 116 (116): 187-193, 2006

10 Mattion N, "Reintroduction of foot-and-mouth disease in Argentina:characterisation of the isolates and development of tools for the control and eradication of the disease" 22 (22): 4149-4162, 2004

11 Aidaros HA, "Regional status and approaches to control and eradication of foot and mouth disease in the Middle East and North Africa" 21 (21): 451-458, 2002

12 Valarcher JF, "Recent spread of FMD virus serotype Asia 1" 157 (157): 30-, 2005

13 Sakamoto K, "Recent outbreaks of foot and mouth disease in countries of east Asia" 21 (21): 459-463, 2002

14 Guo H, "Recent Outbreaks of Foot-and-Mouth Disease Type Asia 1 in China" 53 (53): 29-33, 2006

15 Drake JW, "Rates of spontaneous mutation among RNA viruses" 90 (90): 4171-4175, 1993

16 Domingo E, "Quasispecies dynamics and RNA virus extinction" 107 (107): 129-139, 2005

17 Oem JK, "Pathogenic characteristics of the Korean 2002 isolate of foot-and-mouth disease virus serotype O in pigs and cattle" 138 (138): 204-214, 2008

18 Knowles NJ, "Pandemic strain of foot-and-mouth disease virus serotype O" 11 (11): 1887-1893, 2005

19 Hammond J, "OIE/FAO World Reference Laboratory report, January-March 2009, Foot-and-Mouth Disease"

20 Hammond J, "OIE/FAO World Reference Laboratory report, April-June 2009, Foot-and-Mouth Disease"

21 Baranowski E, "Multiple virulence determinants of foot-and-mouth disease virus in cell culture" 72 (72): 6362-6372, 1998

22 Valarcher JF, "Multiple origins of footand-mouth disease virus serotype Asia 1 outbreaks,2003-2007" 15 (15): 1046-1051, 2007

23 Shin JH, "Molecular pidemiological investigation of foot-and-mouth disease virus in Korea in 2000" 65 (65): 9-16, 2003

24 Arias A, "Molecular intermediates of fitness gain of an RNA virus: characterization of a mutant spectrum by biological and molecular cloning" 82 (82): 1049-1060, 2001

25 Bronsvoort BM, "Molecular epidemiology of foot-and-mouth disease viruses in the Adamawa province of Cameroon" 42 (42): 2186-2196, 2004

26 Konig GA, "Molecular epidemiology of foot-and-mouth disease virus types A and O isolated in Argentina during the 2000-2002 epizootic" 124 (124): 1-15, 2007

27 Bastos AD, "Molecular epidemiology of SAT3-type foot-and-mouth disease" 27 (27): 283-290, 2003

28 Park JH, "Molecular epidemiological analysis and recent distribution of foot-and-mouth disease in the world" 32 (32): 61-68, 2008

29 Mason PW, "Molecular basis of pathogenesis of FMDV" 91 (91): 9-32, 2003

30 Haydon DT, "Low linkage disequilibrium indicative of recombination in footand-mouth disease virus gene sequence alignments" 85 (85): 1095-1100, 2004

31 Shin JH, "Identification and isolation of foot-and-mouth disease virus from primary suspect cases in Korea in 2000" 65 (65): 1-7, 2003

32 Kitching RP, "Global epidemiology and prospects for control of foot-and-mouth disease" 288 : 133-148, 2005

33 Toja M, "Genomic nucleotide sequence of a foot-and-mouth disease virus clone and its persistent derivatives. Implications for the evolution of viral quasispecies during a persistent infection" 64 (64): 161-171, 1999

34 Kuge S, "Genetic variation occurring on the genome of an in vitro insertion mutant of poliovirus type 1" 63 (63): 1069-1075, 1989

35 Bastos AD, "Genetic heterogeneity of SAT-1 type foot-and-mouth disease viruses in southern Africa" 146 (146): 1537-1551, 2001

36 Klein J, "Genetic characterisation of the recent foot-and-mouth disease virus subtype A/IRN/2005" 4 : 122-, 2007

37 Domingo E, "Foot-andmouth disease virus evolution: exploring pathways towards virus extinction" 288 : 149-173, 2005

38 Domingo E, "Foot-and-mouth disease virus populations are quasispecies" 176 : 33-47, 1992

39 Bachrach HL, "Foot-and-mouth disease" 22 : 201-244, 1968

40 Domingo E, "Evolution of foot-and-mouth disease virus" 91 (91): 47-63, 2003

41 Lee KN, "Evidence of recombination in a new isolate of foot-and-mouth disease virus serotype Asia 1" 139 (139): 117-121, 2009

42 Sanyal A, "Emergence of a novel subgroup within the widely circulating lineage of foot-and-mouth disease virus serotype Asia 1 in India" 76 (76): 151-156, 2004

43 Klein J, "Alexandersen S.2008. Epidemiology of foot-and-mouth disease in Landhi Dairy Colony, Pakistan, the world largest Buffalo colony" 5 : 53-, 2008