리도케인의 이온토포레시스에 있어서 이온 피부투과증진제의 영향 = Effect of Ionic Enhancers in the Iontophoresis of Lidocaine

다국어 초록 (Multilingual Abstract)

Lidocaine(2-Diethylaminoaceto-2`, 6`-xylidide) was transdermally delivered by iontophoresis and the effect of enhancer on the delivery of lidocaine was studied. We delivered lidocaine through the skin of hairless mouse using diffusion cell and investigated the effect of the amount of cation salts such as sodium chloride, calcium acetate, zinc acetate and aluminum acetate on the drug delivery. The amounts of transported drugs and adsorbed metal ions were measured by HPLC(High Performance Liquid Chromatography) and AAS(Atomic Absorption Spectrophotometry), respectively. The addition of zinc acetate and aluminum acetate greatly enhanced the delivery of lidocaine. The detection of two metal ions by AAS seemed to support the idea that the astringency effect of these ions were the main reason for the enhancement of transdermal delivery.