Non-alcoholic fatty liver disease in young PCOS women = Non-alcoholic fatty liver disease in young PCOS women

다국어 초록 (Multilingual Abstract)

Objective: To evaluate whether excessive hyperandrogenicity in relation to insulin resistance in adolescents with polycystic ovary syndrome (PCOS) contributes to the progression of metabolic disease and is associated with non-alcoholic fatty liver disease (NAFLD) compared to adults diagnosed with PCOS.
Methods: This was a retrospective cohort study evaluating women with PCOS aged between 13 and 35 years at the point of PCOS diagnosis without any other health condition that could influence liver function. PCOS phenotype, BMI, waist circumference, fasting and 2 hours postprandial insulin and glucose, homeostasis model assessment of insulin resistance, fasting glucose insulin ratio, HDL, LDL, total cholesterol, triglycerides, DHEA-S, total testosterone, SHBG, free androgen index, Anti-mullerian hormone, Liver fibroscan, and abdominal ultrasound were assessed.
Results: In PCOS women with NAFLD compared to those without, hypertension, metabolic syndrome, insulin resistance, SHBG, FAI, weight, BMI, waist circumference, total cholesterol, TG, HDL, LDL, HbA1c, fasting and 2 hours postprandial glucose, and AMH were statistically significantly higher. Interestingly, when adolescents and adults with PCOS were compared, there was no statistically significant difference in weight, BMI, waist circumference, HDL, insulin resistance, SHBG, FAI, obesity, metabolic syndrome, PCOS phenotype, and NAFLD occurrence.
Conclusion: NAFLD frequently arises women with PCOS. Liver evaluation should be considered when patients present with elevated metabolic syndrome factors. Earlier diagnosis can lead to more timely treatment. Even though adolescents with PCOS have not been exposed to an insulin resistant environment for an extended period compared to adults, there were no statistically significant differences in the characteristics studied between adolescents and adults. Regardless of the age at which PCOS is diagnosed, comorbidities can lead to an increased metabolic risk so systematized investigation of NAFLD may be helpful.