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      서러브레드 경주마와 제주마의 경주 능력 향상을 위한 유전체 분석 전략

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      https://www.riss.kr/link?id=A105082876

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      국문 초록 (Abstract)

      말을 활용한 경주는 고대 유럽의 여러 국가들에서 마차 경주 혹은 산악 경주 등의 형태로 이루어졌으며, 고대 그리스 올림픽에서 마차 경주가 정식 종목으로 채택되었다. 서러브레드종은 17...

      말을 활용한 경주는 고대 유럽의 여러 국가들에서 마차 경주 혹은 산악 경주 등의 형태로 이루어졌으며, 고대 그리스 올림픽에서 마차 경주가 정식 종목으로 채택되었다. 서러브레드종은 17세기부터 속도, 체력, 그리고 경주능력을 위해 선택적으로 교배되었다. 그 결과, 18세기부터 귀족들이 향유하는 스포츠로서 서러브레드종을 활용한 경주가 시행되었다. 이후 여러 국가에서 각기 다양한 형태로 발달하여 현재 크게 평지 경주, 장애물 경주, 마차 경주 등으로 발달하였다. 서러브레드 경주마는 300여 년 동안 강력한 선발 육종 전략에 의하여 선택되어 왔기에, 현재 우수한 경주 능력을 갖추고 있다. 말산업은 번식, 조련, 경마 등을 통하여 막대한 경제적 효과를 유발하기에, 말의 경주 능력을 유지하고 극대화하는 것이 필요하다. 최근에 많은 양의 게놈 데이터를 처리하기 위해 차세대 시퀀싱(Next Generation Sequencing; NGS)이 개발되었으며, 이 분석 기술의 현저한 발전을 토대로 우수한 형질을 가진 동물 육종 전략을 쉽게 수행 할 수 있게 되었다. 따라서 뛰어난 경주 능력을 가진 경주마를 선발 육종하기 위해서는 최신 유전체 분석 기술을 활용하는 전략이 필요하다. 본 논문에서는 경주마의 경주 능력을 향상시키기 의한 유전체 분석의 현재의 노력을 알아보고, 마지막으로 경주마와 제주마에서 유전체 분석을 활용하는 전략을 제안할 것이며, 대한민국의 생명자원인 제주마의 선발 육종 전략을 제안할 것이다. 말 산업은 기술, 사회 및 경제분야에서 인간에게 강력한 파급 효과를 주는 동물 중 하나이다. 우리는 국내 고부가가치 말의 원천적인 유전 정보를 확보하고 선발 육종 할 수 있는 체계적인 기술을 확립하여 생산, 연구 업무 등에 대한 일자리 확보에 기여 할 수 있기를 기대한다.

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      다국어 초록 (Multilingual Abstract)

      In ancient times, horse racing was done in ancient European countries in the form of wagon races or mountain races, and wagon racing was adopted as a regular event at the Greek Olympic Games. Thoroughbred horse has been bred since 17th century by inte...

      In ancient times, horse racing was done in ancient European countries in the form of wagon races or mountain races, and wagon racing was adopted as a regular event at the Greek Olympic Games. Thoroughbred horse has been bred since 17th century by intensive selective breeding for its speed, stamina, and racing ability. Then, in the 18th century, horse racing using the Thoroughbred species began to gain popularity among nobles. Since then, horse racing has developed into various forms in various countries and have developed into flat racing, steeplechasing, and harness racing. Thoroughbred racehorse has excellent racing abilities because of powerful selection breeding strategy for 300 years. It is necessary to maintain and maximize horses" ability to race, because horse industries produce enormous economic benefits through breeding, training, and horse racing. Next-generation sequencing (NGS) methods which process large amounts of genomic data have been developed recently. Based on the remarkable development of these genomic analytical techniques, it is now possible to easily carry out animal breeding strategies with superior traits. In order to select breeding racehorse with superior racing traits, the latest genomic analysis techniques have to be introduced. In this paper, we will review the current efforts to improve race performance for racehorses and to examine the research trends of genomic analysis. Finally, we suggest to utilize genomic analysis in Thoroughbred racehorse and Jeju horse, and propose a strategy for selective breeding for Jeju horse, which contributes job creation of Korea.

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      목차 (Table of Contents)

      • 서론
      • 본론
      • 결론
      • References
      • 초록
      • 서론
      • 본론
      • 결론
      • References
      • 초록
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      참고문헌 (Reference)

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      2 Park, K. D., "Whole transcriptome analyses of six thoroughbred horses before and after exercise using RNA-Seq" 13 : 473-, 2012

      3 Mach, N., "Understanding the response to endurance exercise using a systems biology approach: combining blood metabolomics, transcriptomics and miRNomics in horses" 18 : 187-, 2017

      4 Reissmann, M., "Two SNPs in the SILV gene are associated with silver coat colour in ponies" 38 : 1-6, 2007

      5 Gim, J. A., "Transcriptional expression changes of glucose metabolism genes after exercise in thoroughbred horses" 547 : 152-158, 2014

      6 Bower, M. A., "The genetic origin and history of speed in the Thoroughbred racehorse" 3 : 643-, 2012

      7 Soana, S., "The Teeth of the Horse: Evolution and Anatomo-Morphological and Radiographic Study of Their Development in the Foetus" 28 : 273-280, 1999

      8 Gordon, J., "The Horse Industry. Contributing to the Australian Economy" 1-58, 2001

      9 Chowdhary, B. P., "The Horse Genome Derby: racing from map to whole genome sequence" 16 : 109-127, 2008

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      27 Zhou, M., "In silico detection and characteristics of novel microRNA genes in the Equus caballus genome using an integrated ab initio and comparative genomic approach" 94 : 125-131, 2009

      28 Zhou, M., "In silico detection and characteristics of novel microRNA genes in the Equus caballus genome using an integrated ab initio and comparative genomic approach" 94 : 125-131, 2009

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      34 Tryon, R. C., "Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse" 90 : 93-102, 2007

      35 Hill, E., "History and integrity of thoroughbred dam lines revealed in equine mtDNA variation" 33 : 287-294, 2002

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      37 Gim, J. A., "HEpD: A database describing epigenetic differences between Thoroughbred and Jeju horses" 560 : 83-88, 2015

      38 McCue, M. E., "Glycogen synthase (GYS1) mutation causes a novel skeletal muscle glycogenosis" 91 : 458-466, 2008

      39 Ward, T. L., "Glycogen branching enzyme (GBE1) mutation causing equine glycogen storage disease IV" 15 : 570-577, 2004

      40 Jurkat-Rott, K., "Genotype-phenotype correlation and therapeutic rationale in hyperkalemic periodic paralysis" 4 : 216-224, 2007

      41 Do, K. T., "Genomic characterization of the Przewalski's horse inhabiting Mongolian steppe by whole genome re-sequencing" 167 : 86-91, 2014

      42 Solberg, O., "Genomic characterization of equine Interleukin-4 receptor ${\alpha}$-chain (IL4R)" 97 : 187-194, 2004

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      55 Chowdhary, B. P., "Construction of a 5000rad wholegenome radiation hybrid panel in the horse and generation of a comprehensive and comparative map for ECA11" 13 : 89-94, 2002

      56 Wnuk, M., "Changes in DNA methylation patterns and repetitive sequences in blood lymphocytes of aged horses" 36 : 31-48, 2014

      57 Gu, J., "Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses" 42 : 569-575, 2010

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      61 Zabek, T., "Age-related methylation profiles of equine blood leukocytes in the RNASEL locus" 57 : 383-388, 2016

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      63 Jost, U., "A region on equine chromosome 13 is linked to recurrent airway obstruction in horses" 39 : 236-241, 2007

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      65 Brunberg, E., "A missense mutation in PMEL17 is associated with the Silver coat color in the horse" 7 : 46-, 2006

      66 McCue, M. E., "A high density SNP array for the domestic horse and extant Perissodactyla: utility for association mapping, genetic diversity, and phylogeny studies" 8 : e1002451-, 2012

      67 Schnider, D., "A genome-wide association study for equine recurrent airway obstruction in European Warmblood horses reveals a suggestive new quantitative trait locus on chromosome 13" 48 : 691-693, 2017

      68 Hill, E. W., "A genome-wide SNP-association study confirms a sequence variant (g. 66493737C> T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses" 11 : 552-, 2010

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2027 평가예정 재인증평가 신청대상 (재인증)
      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2018-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2015-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2011-08-03 학술지명변경 외국어명 : Korean Journal of Life Science -> Journal of Life Science KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2003-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2001-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.37 0.37 0.42
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
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