Magesium twisilicate is mainly uaed as a nonsytemic antacid andabsrbent.
Magnesium trisilicate when teeated with anacid sxuh as diluted hydrochloric acid in gastric juice decomposes to form Magnesium chloride and colloidal Silicates.
2MgO·3SiO_2 + ...
Magesium twisilicate is mainly uaed as a nonsytemic antacid andabsrbent.
Magnesium trisilicate when teeated with anacid sxuh as diluted hydrochloric acid in gastric juice decomposes to form Magnesium chloride and colloidal Silicates.
2MgO·3SiO_2 + 4Hcl - 2MgCl_2 + H_4Si_3O_8 (or 3SiO_2 + 2H_2O)
Colloidal mixture
The resultng colloidal silicates can protect ahe ulcer frdm further acid and peptic attack and possibly adsorb the pepsin.
It is well known that yield of Magnesium trisilcate produced is greatly affected by the Synthesis condition such as the reactant concentration, reaction temperature and moleatio of reactant solutions as well as by the emperature at which the precipitate is dried and the temperature of washing water, etc.
The purpose of this study is to investigate the optimum synthesis conditions of Magnesium trisilicate. A randomized complete block design suggested by G.E.P. Bdx and K.B. Wagnesium sulfate solution with Sodium silicate solution in this study.
It was found that optimal synthesis conditidns were: Reaction temperature range : 57-90 ℃. Concentration range of reactants (Sodium silicate and Magnesium sulfate) : 19.1-29% molar ratio of the reactants. [Sodium silicate]/[Magnesium sulfate]: 1.47-1.80. temperature range of washing water: 45-48℃ and drying temperature range: 65-82℃
The antacidic activity of five Magnesium trisilicate samples which shows the maximum antacidic efficacy was tested by pharmacopeia acid consuming capacity test.
The five Magnesium trisilicate samples were samples were identified by chemical analysis.