류마티스 관절염 환자의 활막 세포와 T세포의 유착에서 ICAM-1의 역할 = The Roles of Intercellular Adhesion Molecule 1 in T Cell Adhesion Tosynovial Cell in Patients with Rheumatoid Arthritis

다국어 초록 (Multilingual Abstract)

Objective: It has previously been shown that cellular interaction between infiltrating mononuclear cells and synoviocyte are important in the initiation and perpetuation of autoimmune processes in the synovial tissue of patients with rheuamtoid arthritis. Thus, we have investigated the molecular basis of T cell-synovial cell interaction in the cultured synoviocytes from patients with rheumatoid arthritis. Methods: Using an immunohistochemical staining technique and inhibition study with monoclonal antibody, we studied the expression and the function of intercellular adhesion molecule l (ICAM-l) in T cell-synovial cell interaction in the cultured synoviocytes. Results: Expression of ICAM-l was diffusely observed in most components of rheumatoid synovium and readily up-regulated by IL-1. T cell-synovial cell interaction was inhibited by monoclonal antibody aganinst ICAM-1. Conclusion: These results showed that ICAM-l was involed in the cellular interaction between T lymphocytes and synovial cells in patients with rheumatoid arthritis.