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    KCI등재후보 SCOPUS

    Inhibition of L-DOPA-Induced Increase in Dopamine Content by (1R,9S)-β-Hydrastine Hydrochloride in PC12 Cells

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    https://www.riss.kr/link?id=A104470186

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    The effects of BHSH on L-DOPA-induced increase in dopamine content in PC12 cells were investigated. L-DOPA treatment at 20 or 50 mM increased dopamine content after both 24 and 48 h of incubation in PC12 cells.
    However, the co-treatments of BHSH (10-50 mM) with L-DOPA (20 or 50 mM) significantly inhibited the increase of dopamine content induced by L-DOPA. BHSH treatment at 10-50 mM significantly inhibited basal aromatic L-amino acid decarboxylase (AADC) activity in a concentration-dependent manner at 15 min, and then AADC activity was rapidly recovered to the control level at about 2 h. These results indicate that the inhibition of
    AADC activity by BHSH was, in part, contributed to the early-stage decrease of dopamine content induced by LDOPA
    in PC12 cells. Taken together, it is proposed that the short-term inhibition of dopamine biosynthesis by BHSH was mediated by the regulation of tyrosine hydroxylace (TH).
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    The effects of BHSH on L-DOPA-induced increase in dopamine content in PC12 cells were investigated. L-DOPA treatment at 20 or 50 mM increased dopamine content after both 24 and 48 h of incubation in PC12 cells. However, the co-treatments of BHSH (10-5...

    The effects of BHSH on L-DOPA-induced increase in dopamine content in PC12 cells were investigated. L-DOPA treatment at 20 or 50 mM increased dopamine content after both 24 and 48 h of incubation in PC12 cells.
    However, the co-treatments of BHSH (10-50 mM) with L-DOPA (20 or 50 mM) significantly inhibited the increase of dopamine content induced by L-DOPA. BHSH treatment at 10-50 mM significantly inhibited basal aromatic L-amino acid decarboxylase (AADC) activity in a concentration-dependent manner at 15 min, and then AADC activity was rapidly recovered to the control level at about 2 h. These results indicate that the inhibition of
    AADC activity by BHSH was, in part, contributed to the early-stage decrease of dopamine content induced by LDOPA
    in PC12 cells. Taken together, it is proposed that the short-term inhibition of dopamine biosynthesis by BHSH was mediated by the regulation of tyrosine hydroxylace (TH).

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    참고문헌 (Reference)

    1 "activity of L-DOPA decarboxylase in descrete brain regions" 1212-1213, 1970

    2 "The site ofdopamine formation in rat striatum after L-dopa administration" 1981189-197

    3 "The decarboxylationof DOPA in the parkinsonian brain in vivo studies of ananimal model" 95-101, 1980

    4 "Striatal L-dopadecarboxylase activity in Parkinsons desease in vivo implicationsfor the regulation of dopamine synthesis" -1541, 1993

    5 "Rationale for continuous dipaminomimetictherapy of Parkinsons desease" 7-10, 1989

    6 "Palliativeand prophylactic benefits of continuously administereddopaminomimetics in Parkinsons disease" 1994

    7 "Nonaminergicstriatal neurons convert exogenous L-DOPA to dopamine inParkinsonism" 558-563, 1979

    8 "Motor planning isimpaired in Parkinsons desease" 271-276, 1988

    9 "Motor fluctuations in levodopa treatment: Clinical pharmacolog" 36 : 38-42, 1996

    10 "Motor fluctuations in Parkinsonsdisease" 366-1 371, 1988

    1 "activity of L-DOPA decarboxylase in descrete brain regions" 1212-1213, 1970

    2 "The site ofdopamine formation in rat striatum after L-dopa administration" 1981189-197

    3 "The decarboxylationof DOPA in the parkinsonian brain in vivo studies of ananimal model" 95-101, 1980

    4 "Striatal L-dopadecarboxylase activity in Parkinsons desease in vivo implicationsfor the regulation of dopamine synthesis" -1541, 1993

    5 "Rationale for continuous dipaminomimetictherapy of Parkinsons desease" 7-10, 1989

    6 "Palliativeand prophylactic benefits of continuously administereddopaminomimetics in Parkinsons disease" 1994

    7 "Nonaminergicstriatal neurons convert exogenous L-DOPA to dopamine inParkinsonism" 558-563, 1979

    8 "Motor planning isimpaired in Parkinsons desease" 271-276, 1988

    9 "Motor fluctuations in levodopa treatment: Clinical pharmacolog" 36 : 38-42, 1996

    10 "Motor fluctuations in Parkinsonsdisease" 366-1 371, 1988

    11 "Mechaniam of action of short-and long-term L-DOPA treatment in Parkinsonism role of thesurviving nigrostriatal dopaminergic neurons" 149-157, 1984

    12 "Involvement of opioid and dopaminergic mechanisms" isoqui (isoqui): 436-443, 1989

    13 "Inhibitory effectsof bulbocapnine on dopamine biosynthesis in PC12 cells" 244 : 161-164, 1998a

    14 "Inhibitory effects of protoberberinealkaloids from the root of Coptic japonica on catecholaminebiosynthesis in PC12 cell" 62 : 31-34, 1996

    15 "Inhibitory effects of higenamine on dopamine content in PC12 cells" 65 : 452-455, 1999

    16 "Inhibitory effects of coralyne on dopamine content in PC12 cells" 26 : 745-747, 1998b

    17 "Inhibition of monoamine oxidase by isoquinoline derivatives" 50 : 869-877, 1995

    18 "Glucocorticoids increase catecholamine synthesis andstorage in PC12 pheochromocytoma cell culture" 364-370, 1983

    19 "Epinephrine synthesis in the PC12 pheochromocytoma cell line" hadjiconstanti (hadjiconstanti): 139-142, 1986

    20 "Effects ofL-DOPA treatment in Parkinsons disease" 868-876, 1984

    21 "Effects of hydrastine derivatives on dopaminebiosynthesis in PC12 cells" 67 : 609-613, 2001

    22 "Effect of L-dopa aloneand with benserazide on the spontaneous activity of striatalneurons in normal and 6-hydroxydopamine-lesioned rats" 121 : 331-337, 1997

    23 "Dopaminergic transplants in patients with Parkinsonsdisease Neuroanatomical correlates of clinical recovery" 144 : 41-46, 1997

    24 "Detection and function in mammals" 1991

    25 "Decarboxylationof exogenous L-DOPA in rat striatum after lesions of thedopaminergic nigrostriatal neurons the role of striatal capillaries" 244-248, 1980

    26 "Chronic parkinsonism in humans due to a product of meperidine-analog synthesis" 979-980, 1983

    27 "Chemistry of alkaloids of Corydalis-chemical studies onalkaloids of four Corydalis species from Qinghai plateau" 798-800, 1981

    28 "Aromatic L-amino acid decarboxylase: biological characterization and functional role" 26 : 681-696, 1995

    29 "Aromatic L-amino acid decarboxylase: biological characterization and functional role" 26 : 681-696, 1995

    30 "Aromatic L-amino acid decarboxylase modulation and Parkinsons desease" 106 : 91-97, 1995

    31 "Aclinicopathologic study of 100 cases of Parkinsons disease" 140-148, 1993

    32 "A clinically relevantunilateral rat model of Parkinsonian akinesia" 332-333, 1992

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    학술지 이력

    학술지 이력
    연월일 이력구분 이력상세 등재구분
    2023 평가 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
    2020-01-01 등재 등재학술지 유지 (해외등재 학술지 평가) KCI등재
    2011-01-01 등재 등재학술지 유지 (등재유지) KCI등재
    2009-01-01 등재 등재학술지 유지 (등재유지) KCI등재
    2006-01-01 등재 등재학술지 선정 (등재후보2차) KCI등재
    2005-01-01 등재 등재후보 1차 PASS (등재후보1차) KCI등재후보
    2003-07-01 등재 등재후보학술지 선정 (신규평가) KCI등재후보
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    학술지 인용정보

    학술지 인용정보
    기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
    2016 0.18 0.18 0.16
    KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
    0.15 0.15 0.359 0.02
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