Lamotrigine에 의해 발생된 것으로 생각되는 항경련제 과민성 증후군 1예 = Short Report : A Case of Anticonvulsant Hypersensitivity Syndrome thought to be Caused by Lamotrigine

다국어 초록 (Multilingual Abstract)

Anticonvulsant hypersensitivity syndrome (AHS) is a rare and potentially life-threatening drug reaction, which has been associated with aromatic anticonvulsants such as phenytoin, carbamazepine, and phenobarbital. It is characterized by the triad of fever, rash and internal organ involvement, which mostly includes hepatitis. Histopathological findings usually show characteristic erythema multiforme. Lamotrigine is a new antiepileptic drug, chemically distinct from other anticonvulsant medication, however, AHS has recently been documented in patients treated with lamotrigine. We report a case of AHS in a 29-year-old man, thought to have been caused by the use of lamotrigine. (Korean J Dermatol 2006;44(5):620~623)

참고문헌 (Reference)

1 "Prolonged anticonvulsant hypersensitivity syndrome related to lamotrigine in a patient with human immunodeficiency virus" 23 : 415-419, 2002

2 "Lamotrigine-associated anticonvulsant hypersensitivity syndrome" 51 : 1172-1175, 1998

3 "Antiepileptic hypersensitivity syndrome:clinicians beware and be aware" 2 : 34-39, 2002

4 "Anticonvulsant hypersensitivity syndrome.: incidence, prevention and management" 21 : 489-501, 1999

5 "Anticonvulsant hypersensitivity syndrome with an epoxide hydro-lase defect" 140 : 181-183, 1999

6 "Anticonvulsant drug hypersensitivity" 12 : 299-304, 2002

7 "Adding lamotrigine to valproate:incidence of rash and other adverse effects" 40 : 1135-1140, 1999

8 "Acute granulomatous interstitial nephritis and colitis in anticonvulsant hypersensitivity syndrome associated with lamotrigine treatment" 36 : 1034-1040, 2000

9 "A case of anticonvulsant hypersensitivity syndrome induced by carbamazepine" 42 : 523-526, 2004