We investigated the effects of Poncirus trifoliate (P.trifoliate) (Ponciri Fructu, PF) extract and its constituents on gastritis in rats and human gastric cancer cells. The PF 70% ethanol extracts showed the acid-neutralizing capacities and cytotoxici...
We investigated the effects of Poncirus trifoliate (P.trifoliate) (Ponciri Fructu, PF) extract and its constituents on gastritis in rats and human gastric cancer cells. The PF 70% ethanol extracts showed the acid-neutralizing capacities and cytotoxicity against human AGS gastric cancer cells. Neohesperidin and poncirin significantly inhibited HCl.ethanol-induced gastric lesions and increased the mucus content. In pylorus ligated rats, neohesperidin significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. From these results, we could suggest that neohesperidin and poncirin isolated from PF may be useful for the treatment and/or protection of gastritis.