다공성 수산화인회석 혼합 골시멘트의 골내성장 효과 = The Bone Ingrowht Effect of Porous Hydroxyapatite Impregnated Bone Cement

다국어 초록 (Multilingual Abstract)

The purpose of this study is to investigate the bone ingrowth effect of porous hydroxyapatite(HA) impregnated bone cement(polymethylmethacrylate, PMMA) through the histologic and biomechanical analysis. For this study, HA and PMMA were mixed in weight ratio 0:100, 10:90, 30:70, to make 0%, 10%, 30% mixture cylindrical rod shaped sample, sized about 4mm x 10mm. The halves of each sample as control were decalcified to make a comparative histologic and biomechanical analyses of bone ingrowth effect of HA impregnated PMMA. The histologic and biomechanical analyses in vitro and vivo were undertaken to evaluate the bone ingrowth effect of HA impregnated PMMA in several aspects to make a comparative analysis of the interfacial shear strength and a histologic analysis of HA impregnated PMMA in vivo. The comparative analysis of interfacial shear strength using hydraulically controlled machine(INSTRON) in vitro and histologic examination of HA impregnated PMMA in vivo were undertaken using each HA exposed samples(by grinding off and removing the surface coated PMMA) and those processed by surface decalcification, which were harvested from both sides of distal femurs of rabbit at 6 weeks after implantation, respectively. The following results were obtained; 1) In histologic observation using the hard tissue sectioning method with Villaneuva bone stain, there was peri-implant new bone formation in HA impregnated PMMA and more remakable in 30% samples, but an osseointegration into the HA was observed only in 30% sample. And in 10Po and 30% samples decalcifying off the surface HA, peri-implant new bone formation was observed also and more remakable in 30%. But there was no definite difference of bone ingrowth related periimplant new bone formation after and before decalcification about each 10% and 30% samples.