기계적 자극을 고려한 bioreactor 개발

다국어 초록 (Multilingual Abstract)

Articular cartilage has a limited capacity to repair damage resulting from injury or disease because of its avascular nature. In this regard, it has been studied that regeneration of cartilage at in-vitro environment in tissue engineering. And it is reported that mechanical stimuli take a role in improving cell growth in articular cartilage. In this study, we designed a custom bioreactor capable of applying controlled compression to cell-seeded scaffolds. This device consisted of a circulation system and compression system. In circular system, culture chamber was sealed for prohibiting contamination and media solution was circulated by pump. In compression system, mechanical stimuli were controlled by LabVIEW software and mechanical transfer system. Control program was divided two modes such as continuous mode and discrete mode. Therefore, developed bioreactor can be produced two conditions of mechanical stimulation.