Poster Session：PS 1178 ; Cardiology : Comparison of Endothelial Dysfunction between Acute Coronary Syndrome SND Stable Angina Pectoris Patients = Poster Session：PS 1178 ; Cardiology : Comparison of Endothelial Dysfunction between Acute Coronary Syndrome SND Stable Angina Pectoris Patients

다국어 초록 (Multilingual Abstract)

Background: Endothelial dysfunction (ED) is well known to be associated with coronary artery disease (CAD). However, the effect of ED on clinical manifestation of CAD is not well established. This study is designed to assess the difference of endothelial dysfunction between acute coronary syndrome and stable angina pectoris (SAP). Method: Our study has enrolled 224 patients (182 SAP group and 42 ACS group) with chest pain consecutively and coronary angiography was performed for all patients. We used fi ow-medicated dilation (FMD) as detecting tool for endothelial dysfunction. Result: The average FMD value of was 9. 64±4. 10 for SAP group and 8. 17 ± 3. 96 for ACS group. The prevalence of some other medical conditions that are known to be associated with ED was similar between two groups. Although the difference of FMD value was meaningful when compared by t-test (p=0. 040), there was no signifi cant difference after adjusting other variables such as age, diabetes, hypertension, medications (p=0. 454). Age was only important contributing factor for ED in this study (p=0. 035). Conclusion: The severity of endothelial dysfunction was not different between ACS patients and SAP patients. From this result, we can propose that endothelial dysfunction cause coronary artery disease mainly by chronic pathological course such as atherosclerosis. The impact of endothelial dysfunction on plaque rupture or erosion may not be important in development of acute coronary syndrome.