간질환 환자에서 α- D- Mannosidase 와 β- D- Mannosidase 의 활성도 = Activities of α-D-Mannosidase and β-D-Mannosidasein Patients with Liver Diseases

다국어 초록 (Multilingual Abstract)

Background/Aims: We studied the activities of α- and β-D-mannosidase to evaluate their diagnostic significance in liver diseases.
Methods: One hundred fifty one patients with liver diseases were en rolled. The activities of the enzymes were measured by microquantitative spectrophotometry.
Results: The activities of α-D-mannosidase isozymes (neutral and intermediate α-D-mannosidase) were signif icantly high in patients with icteric acute hepatitis (IAH)(48.4 ±25.4, 17.6 ±12.9, 12.2 ±6.2), anicteric acute hepatitis (AAH)(29.9 ±16.0, 11.9 ±5.3, 10.2 ±3.1), cholestatic hepatitis (ChH) (118.3 ±20.6, 50.3 ±12.2, 37.0 ±5.5), icteric liver cirrhosis (ILC)(36.6 ±13.5, 12.0 ±7.8, 9.6 ±4.3), ILC with hepa tocellular carcinoma (HCC)(39.0 ±16.5, 15.1 ±9.4, 11.1 ±5.8). The activity of β-D- mannosidase was also significantly high in patients with IAH (212 ±36), icteric chronic hepatitis (ICH)(193 ±25), ACH (196 ±25), ChH (252 ±38), ILC (188 ±21), ILC with HCC (217 ±55), and ALC with HCC (203 ± 34).
Conclusion: The activitiesof α- and β- D-mannosidase were significantly increased in liver diseases with jaundice, which was related to the increased permeability of the liver cell membrane and the leakage of the enzymes into the blood in large quantities. Serial measurement of these enzymes will be helpful to diagnose liver diseases and to understand the clinical conditions of the patients. (Kor J Gastroenterol 1999;33:211 - 221)