점액세균은 포식활동, 자기방어, 세포 간 신호전달 및 아직까지 알려지지 않은 다른 기능을 위해 다양한 이차대사산물을 생산한다. 점액세균에서 분리된 많은 이차대사산물들은 독특한 작...
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=A105902069
현혜숙 (호서대학교) ; 조경연 (호서대학교) ; Hyun, Hyesook ; Cho, Kyungyun
2018
Korean
KCI등재,SCOPUS
학술저널
175-187(13쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
점액세균은 포식활동, 자기방어, 세포 간 신호전달 및 아직까지 알려지지 않은 다른 기능을 위해 다양한 이차대사산물을 생산한다. 점액세균에서 분리된 많은 이차대사산물들은 독특한 작...
점액세균은 포식활동, 자기방어, 세포 간 신호전달 및 아직까지 알려지지 않은 다른 기능을 위해 다양한 이차대사산물을 생산한다. 점액세균에서 분리된 많은 이차대사산물들은 독특한 작용기작을 가지며 항암, 항세균, 항진균 등과 같은 약학적으로 유용한 생리활성을 보인다. 따라서 전 세계적으로 많은 점액세균 균주들이 분리되었고 이들로부터 다양한 생리활성물질들이 탐색되었다. 하지만 16S rRNA 데이터베이스 분석에 의하면 야생에는 지금까지 분리된 종류 이외에도 다양한 점액세균 종류들이 존재할 것으로 추정되며, 유전체 서열 분석에 의하면 각 점액세균들은 기존에 알려진 물질보다 더 많은 물질을 생산할 수 있는 능력이 있는 것으로 나타났다. 본 총설에서는 점액세균 유래 이차대사산물들과 이들의 유전자, 점액세균에서의 기능, 생합성 유전자의 발현을 조절하는 전사조절인자 등에 대한 최근까지의 연구 현황을 살펴보았다.
다국어 초록 (Multilingual Abstract)
Myxobacteria produce diverse secondary metabolites for predation, self-defense, intercellular signaling, and other unknown functions. Many secondary metabolites isolated from myxobacteria show pharmaceutically useful bioactivity such as anticancer, an...
Myxobacteria produce diverse secondary metabolites for predation, self-defense, intercellular signaling, and other unknown functions. Many secondary metabolites isolated from myxobacteria show pharmaceutically useful bioactivity such as anticancer, antibacterial, and antifungal activities with a unique mechanism of action. Therefore, a large number of myxobacterial strains have been isolated globally and many bioactive compounds have been purified from them. However, 16S rRNA database analysis indicates that there are far more types of myxobacterial species in the wild than have ever been isolated, and genome sequence analysis suggests that each myxobacterium is capable of producing much more metabolites than already known. In this article, the current status of studies on the secondary metabolites from myxobacteria, their biosynthetic genes, biological functions, and transcriptional regulatory factors governing gene expression were reviewed.
참고문헌 (Reference)
1 Medema MH, "antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters" 39 : W339-W346, 2011
2 Weber T, "antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters" 43 : W237-W243, 2015
3 Howard D. McCurdy Jr., "Xanthacin. A bacteriocin of Myxococcus xanthus f b" Canadian Science Publishing 20 (20): 131-135, 1974
4 Yamamoto E, "Vulgatibacter incomptus gen. nov., sp. nov. and Labilithrix luteola gen. nov., sp. nov., two myxobacteria isolated from soil in Yakushima Island, and the description of Vulgatibacteraceae fam. nov., Labilitrichaceae fam. nov. and Anaeromyxobacteraceae fam. nov." 64 : 3360-3368, 2014
5 Belogurov GA, "Transcription inactivation through local refolding of the RNA polymerase structure" 457 : 332335-, 2009
6 János Bérdy, "Thoughts and facts about antibiotics: Where we are now and where we are heading" Springer Nature 65 (65): 385-395, 2012
7 P. Meiser, "The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation" Proceedings of the National Academy of Sciences 103 (103): 19128-19133, 2006
8 Tsai H., "The primary structure of fulvocin C from Myxococcus fulvus" 667 : 213-217, 1981
9 Ryan Keane, "The predatory life cycle of Myxococcus xanthus" Microbiology Society 162 (162): 1-11, 2016
10 Silakowski B, "The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15" 267 : 6476-6485, 2000
1 Medema MH, "antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters" 39 : W339-W346, 2011
2 Weber T, "antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters" 43 : W237-W243, 2015
3 Howard D. McCurdy Jr., "Xanthacin. A bacteriocin of Myxococcus xanthus f b" Canadian Science Publishing 20 (20): 131-135, 1974
4 Yamamoto E, "Vulgatibacter incomptus gen. nov., sp. nov. and Labilithrix luteola gen. nov., sp. nov., two myxobacteria isolated from soil in Yakushima Island, and the description of Vulgatibacteraceae fam. nov., Labilitrichaceae fam. nov. and Anaeromyxobacteraceae fam. nov." 64 : 3360-3368, 2014
5 Belogurov GA, "Transcription inactivation through local refolding of the RNA polymerase structure" 457 : 332335-, 2009
6 János Bérdy, "Thoughts and facts about antibiotics: Where we are now and where we are heading" Springer Nature 65 (65): 385-395, 2012
7 P. Meiser, "The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation" Proceedings of the National Academy of Sciences 103 (103): 19128-19133, 2006
8 Tsai H., "The primary structure of fulvocin C from Myxococcus fulvus" 667 : 213-217, 1981
9 Ryan Keane, "The predatory life cycle of Myxococcus xanthus" Microbiology Society 162 (162): 1-11, 2016
10 Silakowski B, "The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15" 267 : 6476-6485, 2000
11 HERBERT IRSCHIK, "The mechanism of action of myxovalargin A, a peptide antibiotic from Myxococcus fulvus." Japan Antibiotics Research Association 38 (38): 1237-1245, 1985
12 Berleman JE, "The lethal cargo of Myxococcus xanthus outer membrane vesicles" 5 : 474-, 2014
13 Wenzel SC., "The impact of genomics on the exploitation of the myxobacterial secondary metabolome" 26 : 1385-1407, 2009
14 Ziemert N, "The evolution of genome mining in microbes - a review" 33 : 988-1005, 2016
15 Tyc O, "The ecological role of volatile and soluble secondary metabolites produced by soil bacteria" 25 : 280-292, 2017
16 Sasse F, "The chondramides: cytostatic agents from myxobacteria acting on the actin cytoskeleton" 90 : 1559-1563, 1998
17 Herbert Irschik, "The Thuggacins, Novel Antibacterial Macrolides from Sorangium cellulosum Acting against Selected Gram-positive Bacteria" Springer Nature 60 (60): 733-738, 2007
18 Shimkets LJ, "The Prokaryotes" Springer 31-115, 2006
19 Fleta-Soriano E, "The Myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition" 61 : e00739-17, 2017
20 Helge Björn Bode, "The Leupyrrins: A Structurally Unique Family of Secondary Metabolites from the Myxobacterium Sorangium c ellulosum #" American Chemical Society (ACS) 66 (66): 1203-1206, 2003
21 Stoiber K, "Targeting de novo lipogenesis as a novel approach in anti-cancer therapy" 118 : 43-51, 2018
22 Fujimoto H, "Studies on the mode of action of althiomycin" 23 : 271-275, 1970
23 Viehrig K, "Structure and biosynthesis of crocagins: polycyclic posttranslationally modified ribosomal peptides from Chondromyces crocatus" 56 : 7407-7410, 2017
24 안종웅, "Spirodienal, a New Spiroketal from Sorangium cellulosum" 대한화학회 30 (30): 742-744, 2009
25 XueMei Li, "Soraphinol A, a New Indole Alkaloid from Sorangium cellulosum" 대한화학회 28 (28): 835-836, 2007
26 Shimkets LJ, "Social and developmental biology of the myxobacteria" 54 : 473-501, 1990
27 Lucky Mulwa, "Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola" MDPI AG 23 (23): 542-, 2018
28 Fabian Panter, "Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria" Royal Society of Chemistry (RSC) 9 (9): 4898-4908, 2018
29 Paul G. Arnison, "Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature" Royal Society of Chemistry (RSC) 30 (30): 108-160, 2013
30 Louise Kjaerulff, "Pyxipyrrolones: Structure Elucidation and Biosynthesis of Cytotoxic Myxobacterial Metabolites" Wiley 56 (56): 9614-9618, 2017
31 Jörg Kahnt, "Profiling the Outer Membrane Proteome during Growth and Development of the Social Bacterium Myxococcus xanthus by Selective Biotinylation and Analyses of Outer Membrane Vesicles" American Chemical Society (ACS) 9 (9): 5197-5208, 2010
32 J. Muñoz, "Production and properties of a bacteriocin from Myxococcus coralloides D" Wiley 57 (57): 69-74, 1984
33 S. Rachid, "NtcA—A negative regulator of secondary metabolite biosynthesis in Sorangium cellulosum" Elsevier BV 140 (140): 135-142, 2009
34 Jeroen S. Dickschat, "Novel Pyrazines from the MyxobacteriumChondromyces crocatus and Marine Bacteria" Wiley 2005 (2005): 4141-4153, 2005
35 J. Herrmann, "Natural products from myxobacteria: novel metabolites and bioactivities" Royal Society of Chemistry (RSC) 34 (34): 135-160, 2017
36 BRIGITTE KUNZE, "Nannochelins A, B and C, new iron-chelating compounds from Nannocystis exedens (myxobacteria). Production, isolation,physico-chemical and biological properties." Japan Antibiotics Research Association 45 (45): 147-150, 1992
37 Weissman KJ., "Myxobacterial secondary metabolites: bioactivities and modes-of-action" 27 : 1276-1295, 2010
38 Wenzel SC., "Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry" 24 : 1211-1224, 2007
39 Klaus Gerth, "Myxobacteria: proficient producers of novel natural products with various biological activities—past and future biotechnological aspects with the focus on the genus Sorangium" Elsevier BV 106 (106): 233-253, 2003
40 Jong-Woong Ahn, "Multidrug resistant phenotype of Bacillus subtilis spontaneous mutants isolated in the presence of puromycin and lincomycin" American Chemical Society (ACS) 10 (10): 1167-1169, 2008
41 C.N. Castro, "Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function" Elsevier BV 68 (68): 575-584, 2015
42 J. P. EUZéBY, "List of Bacterial Names with Standing in Nomenclature: a Folder Available on the Internet" Microbiology Society 47 (47): 590-592, 1997
43 Burchard RP., "Light-induced lysis and carotenogenesis in Myxococcus xanthus" 91 : 535-545, 1966
44 Douglas F. Browning, "Light-induced carotenogenesis in Myxococcus xanthus: functional characterization of the ECF sigma factor CarQ and antisigma factor CarR" Wiley 48 (48): 237-251, 2003
45 Stein A, "Ixabepilone" 14 : 65-71, 2010
46 Steinmetz H, "Isolation, structure elucidation, and (bio)synthesis of haprolid, a cell-type-specific myxobacterial cytotoxin" 55 : 10113-10117, 2016
47 Steinmetz H, "Isolation, crystal and solution structure determination, and biosynthesis of tubulysins - powerful inhibitors of tubulin polymerization from myxobacteria" 43 : 4888-4892, 2004
48 Yu Jin Kim, "Isolation of Coralmycins A and B, Potent Anti-Gram Negative Compounds from the Myxobacteria Corallococcus coralloides M23" American Chemical Society (ACS) 79 (79): 2223-2228, 2016
49 Tobias Brodmann, "Isolation and Synthesis of Chivotriene, a Chivosazole Shunt Product from Sorangium cellulosum" Wiley 2010 (2010): 5155-5159, 2010
50 Yoon SH, "Introducing EzBioCloud: A taxonomically united database of 16S rRNA and whole genome assemblies" 67 : 1613-1617, 2017
51 W. Plaga, "Intercellular signaling in Stigmatella aurantiaca: Purification and characterization of stigmolone, a myxobacterial pheromone" Proceedings of the National Academy of Sciences 95 (95): 11263-11267, 1998
52 Vahlensieck HF, "Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A" 25 : 95-100, 1994
53 Yang C, "Identification of indothiazinone as a natural antiplatelet agent" 90 : 873-882, 2017
54 Shwan Rachid, "Identification of StiR, the first regulator of secondary metabolite formation in the myxobacterium Cystobacter fuscus Cb f17.1" Elsevier BV 121 (121): 429-441, 2006
55 Beat Nyfeler, "Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B" Public Library of Science (PLoS) 7 (7): e42657-, 2012
56 Schulz S, "Identification and synthesis of volatiles released by the myxobacterium Chondromyces crocatus" 60 : 3863-3872, 2004
57 Suvd Nadmid, "Hyalachelins A–C, Unusual Siderophores Isolated from the Terrestrial Myxobacterium Hyalangium minutum" American Chemical Society (ACS) 16 (16): 4130-4133, 2014
58 Lee Kroos, "Highly Signal-Responsive Gene Regulatory Network Governing Myxococcus Development" Elsevier BV 33 (33): 3-15, 2017
59 E. M. F. Mauriello, "Gliding Motility Revisited: How Do the Myxobacteria Move without Flagella?" American Society for Microbiology 74 (74): 229-249, 2010
60 Trowitzsch W, "Geosmin from earthy smelling culture of Nannocystis exedens (Myxobacterales)" 12 : 257-260, 1981
61 현혜숙, "Genetic and Functional Analyses of the DKxanthene Biosynthetic Gene Cluster from Myxococcus stipitatus DSM 14675" 한국미생물·생명공학회 28 (28): 1068-1077, 2018
62 KLAUS GERTH, "Epothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria). Production, Physico-chemical and Biological Properties." Japan Antibiotics Research Association 49 (49): 560-563, 1996
63 Volz C, "Enhancer binding proteins act as hetero-oligomers and link secondary metabolite production to myxococcal development, motility, and predation" 19 : 1447-1459, 2012
64 Thomas M. A. Gronewold, "Effects of rhizopodin and latrunculin B on the morphology and on the actin cytoskeleton of mammalian cells" Springer Nature 295 (295): 121-129, 1999
65 A. Manor, "Effect of adhesive antibiotic TA on plaque and gingivitis in man" Wiley 16 (16): 621-624, 1989
66 Yasser A Elnakady, "Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells" Elsevier BV 67 (67): 927-935, 2004
67 D. Krug, "Discovering the Hidden Secondary Metabolome of Myxococcus xanthus: a Study of Intraspecific Diversity" American Society for Microbiology 74 (74): 3058-3068, 2008
68 Shwan Rachid, "Deciphering regulatory mechanisms for secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56" Wiley 63 (63): 1783-1796, 2007
69 Brigitte Kunze, "Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum" Springer Nature 10 (10): 199-, 2010
70 Sascha Baumann, "Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity" Wiley 53 (53): 14605-14609, 2014
71 Surup F, "Crocadepsins-depsipeptides from the myxobacterium Chondromyces crocatus found by a genome mining approach" 13 : 267-272, 2018
72 신혜진, "Corallococcus와 Myxococcus 속 점액세균 균주들에 의한 항균 물질의 생산" 한국미생물·생명공학회 41 (41): 44-51, 2013
73 Randi Diestel, "Chivosazoles A and F, Cytostatic Macrolides from Myxobacteria, Interfere with Actin" Wiley 10 (10): 2900-2903, 2009
74 Bryan C. Murray, "Chemistry and biology of tubulysins: antimitotic tetrapeptides with activity against drug resistant cancers" Royal Society of Chemistry (RSC) 32 (32): 654-662, 2015
75 Schifrin A, "Characterization of the gene cluster CYP264B1-geoA from Sorangium cellulosum So ce56: biosynthesis of (+)-eremophilene and its hydroxylation" 16 : 337-344, 2015
76 R. A. Sanford, "Characterization and Description of Anaeromyxobacter dehalogenans gen. nov., sp. nov., an Aryl-Halorespiring Facultative Anaerobic Myxobacterium" American Society for Microbiology 68 (68): 893-900, 2002
77 H. Reichenbach, "Byssovorax cruenta gen. nov., sp. nov., nom. rev., a cellulose-degrading myxobacterium: rediscovery of 'Myxococcus cruentus' Thaxter 1897" Microbiology Society 56 (56): 2357-2363, 2006
78 Jeroen S. Dickschat, "Biosynthesis of Volatiles by the Myxobacterium Myxococcus xanthus" Wiley 5 (5): 778-787, 2004
79 Jeroen S. Dickschat, "Biosynthesis and Identification of Volatiles Released by the Myxobacterium Stigmatella aurantiaca" Wiley 6 (6): 2023-2033, 2005
80 János Bérdy, "Bioactive Microbial Metabolites" Springer Nature 58 (58): 1-26, 2005
81 Reichenbach H., "Bergey's manual of systematic bacteriology" East Lansing 1059-1144, 2005
82 Heinz-Josef Hirsch, "Bacteriocins from Myxococcus fulvus (Myxobacterales)" Springer Nature 115 (115): 45-49, 1977
83 Perez J, "Bacterial predation: 75 years and counting! Environ" 18 : 766-779, 2016
84 J.-S. Kim, "Apicularen A Induces Cell Death through Fas Ligand Up-Regulation and Microtubule Disruption by Tubulin Down-Regulation in HM7 Human Colon Cancer Cells" American Association for Cancer Research (AACR) 13 (13): 6509-6517, 2007
85 Schaberle TF, "Antibiotics from myxobacteria" 31 : 953-972, 2014
86 Xiao Y, "Antibiotic production by myxobacteria plays a role in predation" 193 : 4626-4633, 2011
87 Tomura T, "An unusual diterpene-enhygromic acid and deoxyenhygrolides from a marine myxobacterium, Enhygromyxa sp." 15 : E109-, 2017
88 S. M. RINGEL, "Ambruticin (W7783), a new antifungal antibiotic." Japan Antibiotics Research Association 30 (30): 371-375, 1977
89 Schifrin A, "A single terpene synthase is responsible for a wide variety of sesquiterpenes in Sorangium cellulosum Soce56" 14 : 3385-3393, 2016
90 Weissman KJ., "A brief tour of myxobacterial secondary metabolism" 17 : 2121-2136, 2009
Characterization of anti-inflammatory effect of soybean septapeptide and its molecular mechanism
인간 피부 상재균과 병원성 세균에 대한 Paenibacillus elgii DS381과 그 항균물질의 항균활성
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
2013-12-02 | 학술지명변경 | 외국어명 : The Korean Journal of Microbiology -> Korean Journal of Microbiology | |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2006-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2001-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
1998-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.21 | 0.21 | 0.21 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.26 | 0.24 | 0.48 | 0.02 |