기관지천식 환자에서 집먼지천식 유발검사의 결과예측에 영향을 미치는 인자에 관한 연구 = 기관지천식 환자에서 집먼지천식 유발검사의 결과예측에 영향을 미치는 인자에 관한 연구

다국어 초록 (Multilingual Abstract)

One hundred and twenty nine bronchial asthmatics who visited at the Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine from September 1981 to August 1986 and who showed house dust reactivity on skin prick test, were evaluated about their bronchial responsiveness to house dust extract ( Torii Co. 1: 10 w / v). 1. There were early response group in 18.6% of the patients, dual response group in 47.3%, isolated late response group in 5.4% and none res- ponse group in 28.7%. 2. Negative response rate(25.4%) to house dust bronchoprovocation test(HD-BPT) in a group of age less than 4.0 was significantly lower than that(43.37%) in a group of age more than 40. 3. The skin reactivities of house dust, D. farinae and D. pteronyssinus were in order(dual response group)early response group)negative response group = isolated late rgsponse group) The RAST bound % of the allergens were in the same order. 4. Each one among the skin reactivities of house dust and house dust mites, RAST bound % of the allergens and PC, of methacholone would not be a single factor for predicting PD on house dust challenge. 5. The skin reactivity to D. farinae in the group of PD less than 3BU, PC of methacholine in the group of PD from 3 to 33BU, and the skin reactivities and RAST bound %of house dust and D. farinae in the group of PD more than 33BU would be the factor(s) affecting the development of late response following early response in HD-BPT. With above results skin reactivities and specific IgE of house dust and house dust mites and the degree of nonspecific bronchial hyperreactivity would be related with the asthmatic responses on house dust bronchoprovocation test Because the extract of house dust is mixture of numerous allergens, monocomponent of allergen, especially house dust mite, must be evaluated on the bronchial provocation test. And the isolated late response revealed after challenge of large amount of allergen remains to be evaluated for its pathophysiologic mechanism.