Cutaneous angiosarcoma is a rare, malignant, vascular neoplasm of the skin commonly diagnosed in the head and neck regions. It arises infrequently in the lower extremity. In most cases, the exact etiology of cutaneous angiosarcoma is unclear. Recently...
Cutaneous angiosarcoma is a rare, malignant, vascular neoplasm of the skin commonly diagnosed in the head and neck regions. It arises infrequently in the lower extremity. In most cases, the exact etiology of cutaneous angiosarcoma is unclear. Recently, gene amplifications, especially MYC gene, have been identified as a new etiopathogenesis of angiosarcoma. MYC amplification may induce aberrant angiogenic phenotypes allowing the onset of the malignancy. Meanwhile, in multiple myeloma, MYC is activated and contributes to the malignant phenotype. Therefore, there is a possibility that MYC gene might be the common cause of angiosarcoma and multiple myeloma. Herein, we present the rare case of cutaneous angiosarcoma on lower extremity accompanied by multiple myeloma. An 85-year-old woman visited our department with multiple brownish to black colored nodules with hyperkeratotic crust, which were 0.3 to 0.8 cm in diameter, on the both feet and toes. The excisional biopsy was performed and a diagnosis of cutaneous angiosarcoma was made. At the time of visit, anemia, azotemia, proteinuria and hematuria were found. Immunofixation electrophoresis and bone marrow were performed, so multiple myeloma was diagnosed. We suspected carefully that MYC gene might be the common cause of angiosarcoma and multiple myeloma.