Chitosan reinforced alginate controlled release beads of losartan potassium: design, formulation and in vitro evaluation

다국어 초록 (Multilingual Abstract)

The work investigates the development andoptimization of chitosan-alginate beads containing Losartanpotassium (LP) through ionotropic/external gelationtechnique using 32 factorial design. The effect of polymerblendconcentrations i.e. chitosan and sodium alginate onthe drug encapsulation efficiency (DEE%), and cumulativedrug release after 20 h (R20h %) was optimized. The DEE%of all these beads was within the range of 67.12 ±1.97–89.81 ± 1.52 % with sustained in vitro drug releaseof 80.98–97.13 % over 20 h. The in vitro drug release fromthese beads was followed first order kinetic model. Thebeads were also characterized by FE-SEM, FTIR and XRDanalysis. The swelling of chitosan–alginate beads containingLP were influenced by the pH of the test medium.
Chitosan coated alginate beads were developed as oralsustained delivery carriers for LP in order to improvepatient compliance, to reduce side effects associated with itand also to reduce the dose/dosing frequency in the managementof hypertension.

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