The Osteocyte Network as a Source and Reservoir of Signaling Factors

다국어 초록 (Multilingual Abstract)

Within the past few years, information regarding osteocyte function as been emerging and expanding significantly. No longer is the osteocyte considered a passive cell acting simply as a ‘placeholder’ within mineralized bone. Osteocytes are derived from osteoblast progenitors and in the adult skeleton compose 90-95% of all bone cells. Therefore, the function of these cells in the adult and aging skeleton has become the focus of recent investigation. These cells are proving to be multifunctional, ranging from mechanotransduction,to regulation of mineral homeostasis, to control of bone remodeling. The osteocyte as a source and reservoir of signaling factors important in health and maintenance of the adult skeleton is addressed in this review.

참고문헌 (Reference)

1 Sittichockechaiwut A, "Use of rapidly mineralising osteoblasts and short periods of mechanical loading to accelerate matrix maturation in 3D scaffolds" 44 : 822-829, 2009

2 Dallas S, "Unraveling osteocyte signaling networks:Meeting Report from the 31st Annual Meeting of the American Society for Bone and Mineral Research:September 11-15,2009 in Denver" 7 : 88-92, 2010

3 Sillar-Jackson AJ, "The role of α5 integrin as a mechanosensor in the regulation of connexin 43 hemichannel release of prostaglandin in response to mechanical stress" 21 : S72-, 2006

4 Klein-Nulend J, "The osteocyte. In: Principles of bone biology" Academic Press 2008

5 Tatsumi S, "Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction" 5 : 464-475, 2007

6 Paszty C, "Sclerostin: A gem from the genome leads to bone building antibodies" 2010

7 Malone AM, "Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism" 104 : 13325-13330, 2007

8 Bonewald LF, "Osteocytes. In: Osteoporosis, 3rd ed" Elsevier Academic Press 169-190, 2007

9 Bonewald LF, "Osteocytes,mechanosensing and Wnt signaling" 42 : 606-615, 2008

10 Bonewald LF, "Osteocytes as dynamic,multifunctional cells" 1116 : 281-290, 2007

11 Qing H, "Osteocyte perilacunar remodeling is regulated hormonally, but not by mechanical unloading" 1 : Mo0255-, 2009

12 Kramer I, "Osteocyte Wnt/b-catenin signaling is required for normal bone homeostasis" 30 : 3071-3085, 2010

13 Barry K, "Mice lacking PTH receptors in Osteocytes failed to respond to intermittent administration of PTH" 2009

14 Bonewald LF, "Mechanosensation and transduction in osteocytes" 3 : 7-15, 2006

15 Barragan-Adjemian C, "Mechanism by which MLO-A5 late osteoblasts/early osteocytes mineralize in culture:similarities with mineralization of lamellar bone" 79 : 340-353, 2006

16 Mikuni-Takagaki Y, "Matrix mineralization and the differentiation of osteocyte-like cells in culture" 10 : 231-242, 1995

17 Feng JQ, "Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism" 38 : 1310-1315, 2006

18 Xia X, "Glucocorticoid induced autophagy in osteocytes" 2010

19 Roelofs AJ, "Fluorescent risedronate analogs reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo" 25 : 606-616, 2010

20 Fritton SP, "Fluid and solute transport in bone:flow-induced mechanotransduction" 41 : 347-374, 2009

21 Kato Y, "Establishment of an osteocyte-like cell line,MLO-Y4" 12 : 2014-2023, 1997

22 Kato Y, "Establish-ment of an osteoid preosteocyte-like cell MLO-A5 that spontaneously mineralizes in culture" 16 : 1622-1633, 2001

23 Dallas SB, "Dynamics of the transition from osteoblast to osteocyte" 1192 : 437-443, 2010

24 O’Brien CA, "Control of bone mass and remodeling by PTH receptor signaling in osteocytes" 3 : e2942-, 2008

25 Xiao Z, "Conditional deletion and/or disruption of Pkd1 in osteocytes results in a significant reduction in anabolic response to mechanical loading"

26 Kamel S, "Collagen assembly dynamics in living osteoblasts" 1 : 2010

27 Xiao Z, "Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression" 281 : 30884-30895, 2006

28 Woo SB, "Cell line IDG-SW3 expresses Dmp1-GFP, SOST and FGF23 in vitro and promotes new bone formation in vivo"

29 Kogianni G, "Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction" 23 : 915-927, 2008