1 Song XQ, "The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia" 65 : 481-488, 2009
2 Cochran WG, "The combination of estimates from different experiments" 10 : 101-129, 1954
3 Engel GL, "The clinical application of the biopsychosocial model" 6 : 101-124, 1981
4 Oris C, "The biomarker S100B and mild traumatic brain injury: a meta-analysis" 141 : e20180037-, 2018
5 Cuthbert BN, "The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology" 13 : 28-35, 2014
6 Page MJ, "The PRISMA 2020 statement: an updated guideline for reporting systematic reviews" 372 : n71-, 2021
7 Overall JE, "The Brief Psychiatric Rating Scale (BPRS):recent developments in ascertainment and scaling" 24 : 97-99, 1988
8 Aleksovska K, "Systematic review and meta-analysis of circulating S100B blood levels in schizophrenia" 9 : e106342-, 2014
9 Gógl G, "Structural basis of ribosomal S6 kinase 1 (RSK1) inhibition by S100B protein:modulation of the extracellular signal-regulated kinase (ERK) signaling cascade in a calcium-dependent way" 291 : 11-27, 2016
10 Hedges LV, "Statistical methods for meta-analysis" Academic Press 1985
11 Tzoulaki I, "Size at birth, weight gain over the life course, and lowgrade inflammation in young adulthood: northern Finland 1966 Birth Cohort study" 29 : 1049-1056, 2008
12 Milleit B, "Serum S100B protein is specifically related to white matter changes in schizophrenia" 10 : 33-, 2016
13 Schroeter ML, "Serum S100B is increased during early treatment with antipsychotics and in deficit schizophrenia" 62 : 231-236, 2003
14 McCutcheon RA, "Schizophrenia-an overview" 77 : 201-210, 2020
15 O’Connell G, "Schizophrenia risk genes: implications for future drug development and discovery" 81 : 1367-1373, 2011
16 Andreasen NC, "Scale for the assessment of positive symptoms (SAPS)"
17 Li D, "S100B suppresses the differentiation of C3H/10T1/2 murine embryonic mesenchymal cells into osteoblasts" 14 : 3878-3886, 2016
18 Steiner J, "S100B serum levels in schizophrenia are presumably related to visceral obesity and insulin resistance" 2010 : 480707-, 2010
19 Rothermundt M, "S100B serum levels and long-term improvement of negative symptoms in patients with schizophrenia" 29 : 1004-1011, 2004
20 Bianchi R, "S100B protein stimulates microglia migration via RAGE-dependent up-regulation of chemokine expression and release" 286 : 7214-7226, 2011
21 Riuzzi F, "S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner" 124 (124): 2389-2400, 2011
22 Businaro R, "S100B protects LAN-5 neuroblastoma cells against Abeta amyloid-induced neurotoxicity via RAGE engagement at low doses but increases Abeta amyloid neurotoxicity at high doses" 83 : 897-906, 2006
23 Rothermundt M, "S100B in brain damage and neurodegeneration" 60 : 614-632, 2003
24 Rickmann M, "S100 protein expression in subpopulations of neurons of rat brain" 67 : 977-991, 1995
25 Cochran AJ, "S-100 protein remains a practical marker for melanocytic and other tumours" 3 : 325-330, 1993
26 Laird NM, "Random-effects models for longitudinal data" 38 : 963-974, 1982
27 Cannon TD, "Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk" 77 : 147-157, 2015
28 Moher D, "Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement" 339 : b2535-, 2009
29 Ling SH, "Plasma S-100B protein in Chinese patients with schizophrenia: comparison with healthy controls and effect of antipsychotics treatment" 41 : 36-42, 2007
30 Sarandol A, "Oxidative-antioxidative systems and their relation with serum S100 B levels in patients with schizophrenia : effects of short term antipsychotic treatment" 31 : 1164-1169, 2007
31 Begg CB, "Operating characteristics of a rank correlation test for publication bias" 50 : 1088-1101, 1994
32 Youn JH, "Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion" 177 : 7889-7897, 2006
33 Schroeter ML, "Neuron-specific enolase is unaltered whereas S100B is elevated in serum of patients with schizophrenia--original research and meta-analysis" 167 : 66-72, 2009
34 Hendouei N, "Negative correlation between serum S100B and leptin levels in schizophrenic patients during treatment with clozapine and risperidone: preliminary evidence" 15 : 323-330, 2016
35 Bonaldi T, "Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion" 22 : 5551-5560, 2003
36 Weinhard L, "Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction" 9 : 1228-, 2018
37 Miller BJ, "Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects" 70 : 663-671, 2011
38 Cuijpers P, "Meta-analyses in mental health research. A practical guide"
39 Higgins JP, "Measuring inconsistency in meta-analyses" 327 : 557-560, 2003
40 O’Connell K, "Levels of S100B are raised in female patients with schizophrenia" 13 : 146-, 2013
41 Romeo B, "Kinetics of cytokine levels during antipsychotic treatment in schizophrenia: a meta-analysis" 21 : 828-836, 2018
42 Şahin M, "Jamovi: an easy to use statistical software for the social scientists" 6 : 670-692, 2019
43 Khandaker GM, "Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment" 2 : 258-270, 2015
44 Lara DR, "Increased serum S100B protein in schizophrenia : a study in medication-free patients" 35 : 11-14, 2001
45 Kim HR, "Increased serum S100B protein in chronic schizophrenic patients in Korea" 45 : 1561-1563, 2007
46 Qi LY, "Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics" 462 : 113-117, 2009
47 Zhang XY, "Increased serum S100B in never-medicated and medicated schizophrenic patients" 44 : 1236-1240, 2010
48 Schmitt A, "Increased serum S100B in elderly, chronic schizophrenic patients : negative correlation with deficit symptoms" 80 : 305-313, 2005
49 Uzbay T, "Increased plasma agmatine levels in patients with schizophrenia" 47 : 1054-1060, 2013
50 Steiner J, "Increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia are not related to a degenerative release of glial fibrillar acidic protein, myelin basic protein and neurone-specific enolase from glia or neurones" 77 : 1284-1287, 2006
51 Šakić M, "Increased calcium-independent lipoprotein phospholipase A2 but not protein S100 in patients with schizophrenia" 28 : 45-50, 2016
52 Rothermundt M, "Increased S100B blood levels in unmedicated and treated schizophrenic patients are correlated with negative symptomatology" 6 : 445-449, 2001
53 Michetti F, "Immunohistochemical localization of S-100-containing cells in non-nervous structures of the human eye" 10 : 765-773, 1986
54 van Kesteren CF, "Immune involvement in the pathogenesis of schizophrenia:a meta-analysis on postmortem brain studies" 7 : e1075-, 2017
55 World Health Organization, "ICD-10: international statistical classification of diseases and related health problems: 10th revision (2nd ed)"
56 Hong W, "Higher plasma S100B concentrations in schizophrenia patients, and dependently associated with inflammatory markers" 6 : 27584-, 2016
57 Yilmaz N, "High mobility group box-1 levels in schizophrenia: potential biomarker of remission phase" 40 : 295-301, 2021
58 Allsopp K, "Heterogeneity in psychiatric diagnostic classification" 279 : 15-22, 2019
59 Steiner J, "Haloperidol and clozapine decrease S100B release from glial cells" 167 : 1025-1031, 2010
60 Yang M, "HMGB1-induced endothelial cell pyroptosis is involved in systemic inflammatory response syndrome following radiofrequency ablation of hepatic hemangiomas" 11 : 7555-7567, 2019
61 Brezniceanu ML, "HMGB1 inhibits cell death in yeast and mammalian cells and is abundantly expressed in human breast carcinoma" 17 : 1295-1297, 2003
62 Kang R, "HMGB1 in health and disease" 40 : 1-116, 2014
63 Sha Y, "HMGB1 develops enhanced proinflammatory activity by binding to cytokines" 180 : 2531-2537, 2008
64 Murray CJ, "Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study" 349 : 1436-1442, 1997
65 Rothermundt M, "Glial cell dysfunction in schizophrenia indicated by increased S100B in the CSF" 9 : 897-899, 2004
66 Rothermundt M, "Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol" 31 : 361-364, 2007
67 Dennison CA, "Genome-wide association studies in schizophrenia: recent advances, challenges and future perspective" 217 : 4-12, 2020
68 Andersson U, "Extracellular HMGB1 as a therapeutic target in inflammatory diseases" 22 : 263-277, 2018
69 Starkie R, "Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans" 17 : 884-886, 2003
70 Xiong Z, "Enhanced calcium transients in glial cells in neonatal cerebellar cultures derived from S100B null mice" 257 : 281-289, 2000
71 Wiesmann M, "Elevated plasma levels of S-100b protein in schizophrenic patients" 45 : 1508-1511, 1999
72 Canetta S, "Elevated maternal C-reactive protein and increased risk of schizophrenia in a national birth cohort" 171 : 960-968, 2014
73 Dai N, "Different serum protein factor levels in first-episode drug-naive patients with schizophrenia characterized by positive and negative symptoms" 74 : 472-479, 2020
74 Nettleton JA, "Dietary patterns are associated with biochemical markers of inflammation and endothelial activation in the Multi-Ethnic Study of Atherosclerosis (MESA)" 83 : 1369-1379, 2006
75 Wardenaar KJ, "Diagnostic heterogeneity in psychiatry: towards an empirical solution" 11 : 201-, 2013
76 American Psychiatric Association, "Diagnostic and statistical manual of mental disorders" American Psychiatric Association 2013
77 Gattaz WF, "Decreased S100-beta protein in schizophrenia: preliminary evidence" 43 : 91-95, 2000
78 Morera-Fumero AL, "Day/night changes in serum S100B protein concentrations in acute paranoid schizophrenia" 75 : 207-212, 2017
79 Zindel J, "DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation" 15 : 493-518, 2020
80 Xiong P, "Combining serum protein concentrations to diagnose schizophrenia: a preliminary exploration" 75 : e794-e801, 2014
81 Chen S, "Cognitive dysfunction correlates with elevated serum S100B concentration in drugfree acutely relapsed patients with schizophrenia" 247 : 6-11, 2017
82 Lee J, "Cigarette smoking and inflammation: cellular and molecular mechanisms" 91 : 142-149, 2012
83 Mousa RF, "Chronic fatigue syndrome and fibromyalgia-like symptoms are an integral component of the phenome of schizophrenia: neuro-immune and opioid system correlates" 36 : 169-183, 2021
84 Zhang XY, "Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia" 65 : 940-947, 2004
85 Song X, "Changes in pro-inflammatory cytokines and body weight during 6-month risperidone treatment in drug naïve, first-episode schizophrenia" 231 : 319-325, 2014
86 Donato R, "Calcium-independent, pH-regulated effects of S-100 proteins on assembly-disassembly of brain microtubule protein in vitro" 263 : 106-110, 1988
87 Egger M, "Bias in meta-analysis detected by a simple, graphical test" 315 : 629-634, 1997
88 Eaton WW, "Association of schizophrenia and autoimmune diseases: linkage of Danish national registers" 163 : 521-528, 2006
89 Khandaker GM, "Association between circulating levels of C-reactive protein and positive and negative symptoms of psychosis in adolescents in a general population birth cohort" 143 : 534-542, 2021
90 Tourjman V, "Antipsychotics’ effects on blood levels of cytokines in schizophrenia: a meta-analysis" 151 : 43-47, 2013
91 Barker V, "An integrated biopsychosocial model of childhood maltreatment and psychosis" 206 : 177-180, 2015
92 Land W, "Allograft injury mediated by reactive oxygen species: from conserved proteins of Drosophila to acute and chronic rejection of human transplants. Part II: role of reactive oxygen species in the induction of the heat shock response as a regulator of innate" 17 : 31-44, 2003
93 Kozłowska E, "Alarmins (IL-33, sST2, HMGB1, and S100B) as potential biomarkers for schizophrenia" 138 : 380-387, 2021
94 Capuzzi E, "Acute variations of cytokine levels after antipsychotic treatment in drug-naïve subjects with a first-episode psychosis: a meta-analysis" 77 : 122-128, 2017
95 Saha S, "A systematic review of mortality in schizophrenia:is the differential mortality gap worsening over time?" 64 : 1123-1131, 2007
96 Duval S, "A nonparametric “trim and fill” method of accounting for publication bias in meta-analysis" 95 : 89-98, 2000
97 Iager AC, "A negative symptom rating scale" 16 : 27-36, 1985
98 Orwin RG, "A fail-safe N for effect size in meta-analysis" 8 : 157-159, 1983