Background: Previous studies have identified differences in skin surface and intestinal microbiota between healthy humans and patients with atopic dermatitis. However, the microbiome of the skin has very different characteristics depending on the dry,...
Background: Previous studies have identified differences in skin surface and intestinal microbiota between healthy humans and patients with atopic dermatitis. However, the microbiome of the skin has very different characteristics depending on the dry, wet, and oily areas.
Objectives: This study was purposed to identify whether the skin microflora and tryptophan metabolites are different between atopic dermatitis patients group and normal control group.
Methods: Skin samples of 60 volunteers were collected from the nose, abdomen, antecubital fossa by swabs and tapping, and stool samples were collected with cotton swabs.
Results: In the atopic dermatitis patients, the Kocuria, Megamonas, Unassigned, Enterocloster, Tyzzerella, Veillonella, and Rhodospirillum are increased in the fecal samples. The Comamonas, Finegoldia, Haemophilus, Porphyromonas, Staphylococcus, Neisseria, Thermodesulfobacterium, and Prevotella are increased in skin samples of the atopic dermatitis group. Indole-3-lactic acid, a tryptophan metabolite, was significantly decreased in skin of the atopic dermatitis patients group.
Conclusion: This study showed the skin microflora and tryptophan metabolites are different between atopic dermatitis patients group and normal control group.