지각과 상엽 혼합추출물이 지질 개선에 미치는 영향 = The Improvement of Mixed Extracts of Fructus Aurantii and Mulberry Leaves on Lipid Metabolism

다국어 초록 (Multilingual Abstract)

Background : Diabetes is a chronic disease characterized by deficiency of insulin. It has been reported that Fructus aurantii and mulberry leaves have the effect of anti-diabetes. Methods : To investigate the improvement of mixed extracts of Fructus aurantii and mulberry leaves on lipid metabolism, we performed double-blinded, randomized and placebo-controlled multi-center clinical trial. Results : Mixed extracts of Fructus aurantii and mulberry leaves significantly reduced total cholesterol. Conclusion : These results suggest that mixed extracts of Fructus aurantii and mulberry leaves improve lipid metabolism.

참고문헌 (Reference)

1 김호철, "한약약리학" 집문당 105-106, 2001

2 안덕균, "한국본초도감" 교학사 602-603, 1999

3 안덕균, "한국본초도감" 교학사 462-, 1999

4 UK Prospective Diabetes Study(UKPDS) Group, "Tight blood pressure control and risk of macrovascular complications in type 2 diabetes:UKPDS 38" 317 : 703-713, 1998

5 Jung UJ, "The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ- db/db mice" 134 (134): 2499-2503, 2004

6 Klein R, "The Wisconsin Epidemiologic Study of Diabetic Retinopathy. III. Pre- valence and risk of diabetic retinopathy when age at diagnosis is 30 or more years" 102 : 527-532, 1984

7 American Diabetes Association, "Standards of Medical Care for Patients With Dia- betes Mellitus" 25 : 33-49, 2002

8 The Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus, "Report of the Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus" 26 : 5-20, 2003

9 The Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus, "Report of the Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus" 26 : 5-20, 2003

10 The Scandinavian Simvastatin Survival Study Group, "Randomized trial of chole- sterol lowering in 4444 patients with coronary heart disease:The Scandinavian Simvastatin Survival Study(4S)" 344 : 1383-1389, 1994

11 The Scandinavian Simvastatin Survival Study Group, "Randomized trial of chole- sterol lowering in 4444 patients with coronary heart disease:The Scandinavian Simvastatin Survival Study(4S)" 344 : 1383-1389, 1994

12 Saydah SH, "Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes" 291 : 335-342, 2004

13 Li WL, "Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus" 92 : 1-21, 2004

14 김소영, "Multiple low dose streptozotocin으로 유도된 고혈당 흰쥐에서 인삼, 상엽 단독 및 복합처방의 항당뇨효과"

15 UK Prospective Diabetes Study(UKPDS) Gr, "Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes:UKPDS 33" 352 : 837-853, 1998

16 Reaven GM, "Insulin resistance and com- pensatory hyperinsulinemia:role in hyper- tension, dyslipidemia and coronary heart disease" 121 : 1283-1288, 1991

17 Grundy SM, "Hypertriglyceridemia, insulin resistance, and the metabolic syndrome" 83 : 25-29\, 1999

18 King H, "Global burden of diabetes, 1995-2025:prevalence, numerical estimates, and projections" 21 (21): 1414-1431, 1998

19 Huang YT, "Fructus aurantii reduced portal pressure in portal hyper- tensive rats" 57 (57): 2011-2020, 1995

20 American Diabetes Association, "Evidence- Based Nutrition Principles and Reco- mmendations for the Treatment and Pre- vention of Diabetes and Related Com- plications" 25 : 50-60, 2002

21 Andallu B, "Effect of mul- berry(Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes" 314 (314): 47-53, 2001

22 Jung UJ, "Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice." 38 (38): 1134-1145, 2006

23 Andallu B, "Antio- xidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin- diabetic rats" 338 (338): 3-10, 2003

24 Kang MK, "Anti- diabetes effect of Mori Folium and Aurantii Fructus on diabetes rats in- duced by streptozotocin. 19th FAOBMB Seoul Conference"

25 통계청, "2006년 사망 및 사망원인통계결과"