<P><B>Aims: </B> To investigate the relationship between the expression of autophagy‐related proteins, including beclin‐1, light chain (LC) 3A, LC3B, and p62, and prognosis in invasive breast cancer.</P>&...
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=A107613257
2013
-
SCOPUS,SCIE
학술저널
275-286(12쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Aims: </B> To investigate the relationship between the expression of autophagy‐related proteins, including beclin‐1, light chain (LC) 3A, LC3B, and p62, and prognosis in invasive breast cancer.</P>&...
<P><B>Aims: </B> To investigate the relationship between the expression of autophagy‐related proteins, including beclin‐1, light chain (LC) 3A, LC3B, and p62, and prognosis in invasive breast cancer.</P><P><B>Methods and results: </B> We constructed tissue microarrays from the breast cancer cells of 489 patients, and classified molecular subtypes using surrogate immunohistochemical stains. The tumoral expression levels of LC3A and LC3B were highest in triple‐negative breast cancer (TNBC) (<I>P</I> < 0.001), whereas these types of tumour had the lowest expression levels of these markers in the stroma (<I>P</I> = 0.005 and <I>P</I> < 0.001, respectively). Cytoplasmic beclin‐1 expression was highest in TNBC, but nuclear expression was lowest (<I>P</I> < 0.001). p62 cytoplasmic and nuclear expression were highest in HER2‐type tumours (<I>P</I> = 0.001 and <I>P</I> < 0.001, respectively). Tumoral LC3A and LC3B expression were associated with high histological grade (<I>P</I> < 0.001, and <I>P</I> < 0.028, respectively), but nuclear p62 expression was associated with lower histological grade (<I>P</I> = 0.004).</P><P><B>Conclusions: </B> Autophagy‐related markers are differentially expressed according to the molecular subtype of breast cancer. In particular, expression of LC3A, LC3B and beclin‐1 was highest in TNBC tumour cells, whereas that of LC3A and LC3B in the tumour stroma was lowest in TNBC.</P>