본 연구에서는 울금(Curcuma longa L.)의 다양한 추출물을 대상으로 5-alpha reductase의 활성 저해 정도를 측정하였다. 5-Alpha reductase는 T에서 활성형 남성호르몬인 DHT로 전환을 담당하며, 전립선비대...
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https://www.riss.kr/link?id=A99915031
2014
Korean
KCI등재,SCOPUS
학술저널
318-322(5쪽)
2
0
상세조회0
다운로드국문 초록 (Abstract)
본 연구에서는 울금(Curcuma longa L.)의 다양한 추출물을 대상으로 5-alpha reductase의 활성 저해 정도를 측정하였다. 5-Alpha reductase는 T에서 활성형 남성호르몬인 DHT로 전환을 담당하며, 전립선비대...
본 연구에서는 울금(Curcuma longa L.)의 다양한 추출물을 대상으로 5-alpha reductase의 활성 저해 정도를 측정하였다. 5-Alpha reductase는 T에서 활성형 남성호르몬인 DHT로 전환을 담당하며, 전립선비대에서는 혈액에서 DHT농도가 높다. Rat의 전립선조직 균질액과 5-alpha reductase를 과발현시킨 LNCaP 세포 균질액을 대상으로 측정한 결과, 100 μg/mL의 농도에서 울금의 열수추출물(CL-HW)과 20% 에탄올추출물(CL-E20)이 5-alpha reductase 활성을 효과적으로 저해하였다. 특히 CL-HW는 100 μg/mL의 농도에서 80% 이상의 유의적 억제효과를 보였으며, CL-E20은 50 μg/mL의 농도부터 80% 이상의 감소효과를 보였다. 이 같은 결과에서 CL-HW 및 CL-E20은 5-alpha reductase의 억제활성이 있으며, 이는 전립선비대 치료소재로 개발될 수 있는 가능성이 있음을 제안한다.
다국어 초록 (Multilingual Abstract)
5-Alpha reductase Ⅱ, which converts testosterone (T) to dihydrotestosterone (DHT), is a crucial enzyme Ⅱ in benign prostatic hyperplasia. Inhibitory effects of Curcuma longa L. (CL) extracts on 5-alpha reductase Ⅱ activity were investigated in r...
5-Alpha reductase Ⅱ, which converts testosterone (T) to dihydrotestosterone (DHT), is a crucial enzyme Ⅱ in benign prostatic hyperplasia. Inhibitory effects of Curcuma longa L. (CL) extracts on 5-alpha reductase Ⅱ activity were investigated in rat prostate tissue homogenates as well as LNCaP cells expressing human 5-alpha reductase Ⅱ. Hot water extract (CL-HW) of Curcuma longa L. significantly inhibited 5-alpha reductase activity by over 80% at a concentration of 100 μg/mL, whereas 20% ethanol extracts (CL-E20) of Curcuma longa L. exhibited significant inhibitory activity from 50 μg/mL. These results indicated that Curcuma longa L is a potent 5-alpha reductase Ⅱ inhibitor for benign prostatic hyperplasia treatment.
참고문헌 (Reference)
1 Shin IS, "Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia" 50 : 884-888, 2012
2 Jean-Francois Bisson, "Therapeutic Effect of ACTICOA Powder, a Cocoa Polyphenolic Extract, on Experimentally Induced Prostate Hyperplasia in Wistar-Unilever Rats" 한국식품영양과학회 10 (10): 628-635, 2007
3 Hiipakka RA, "Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols" 63 : 1165-1176, 2002
4 Jugjeet S. Ramkissoon, "Relationship Between Total Phenolic Content, Antioxidant Potential, and Antiglycation Abilities of Common Culinary Herbs and Spices" 한국식품영양과학회 15 (15): 1116-1123, 2012
5 Pais P, "Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5alpha-reductase Ⅱ" 27 : 555-563, 2010
6 Ejike CE, "Inhibition of the experimental induction of benign prostatic hyperplasia: a possible role for fluted pumpkin (Telfairia occidentalis Hook f.)seeds" 87 : 218-224, 2010
7 Chandrasekaran CV, "Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction" 5 : 71-79, 2013
8 Chaudhary UB, "Finasteride" 6 : 873-881, 2010
9 Jang S, "Establishment of type Ⅱ 5alpha-reductase over-expressing cell line as an inhibitor screening model" 107 : 245-252, 2007
10 Wang X, "Establishment of a novel model for studying the effects of extracts of Chinese herb medicine on human type Ⅱ 5alpha-reductase in vitro" 130 : 1207-1214, 2010
1 Shin IS, "Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia" 50 : 884-888, 2012
2 Jean-Francois Bisson, "Therapeutic Effect of ACTICOA Powder, a Cocoa Polyphenolic Extract, on Experimentally Induced Prostate Hyperplasia in Wistar-Unilever Rats" 한국식품영양과학회 10 (10): 628-635, 2007
3 Hiipakka RA, "Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols" 63 : 1165-1176, 2002
4 Jugjeet S. Ramkissoon, "Relationship Between Total Phenolic Content, Antioxidant Potential, and Antiglycation Abilities of Common Culinary Herbs and Spices" 한국식품영양과학회 15 (15): 1116-1123, 2012
5 Pais P, "Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5alpha-reductase Ⅱ" 27 : 555-563, 2010
6 Ejike CE, "Inhibition of the experimental induction of benign prostatic hyperplasia: a possible role for fluted pumpkin (Telfairia occidentalis Hook f.)seeds" 87 : 218-224, 2010
7 Chandrasekaran CV, "Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction" 5 : 71-79, 2013
8 Chaudhary UB, "Finasteride" 6 : 873-881, 2010
9 Jang S, "Establishment of type Ⅱ 5alpha-reductase over-expressing cell line as an inhibitor screening model" 107 : 245-252, 2007
10 Wang X, "Establishment of a novel model for studying the effects of extracts of Chinese herb medicine on human type Ⅱ 5alpha-reductase in vitro" 130 : 1207-1214, 2010
11 김유나, "Effect of Phellius linteus water extract on benign prostatic hyperplasia" 한국영양학회 7 (7): 172-177, 2013
12 Gasco M, "Dose-response effect of Red Maca(Lepidium meyenii)on benign prostatic hyperplasia induced by testosterone enanthate" 4 : 460-464, 2007
13 강동일, "Current Status of 5α-Reductase Inhibitors in Prostate Disease Management" 대한비뇨기과학회 54 (54): 213-219, 2013
14 Um MY, "Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase" 113 : 152-157, 2013
15 Stefanska B, "Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus-insights into its mechanisms of action" 166 : 2209-2211, 2012
16 Ho JN, "Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes" 2 : 1833-1840, 2012
17 Sun J, "A review on steroidal 5α-reductase inhibitors for treatment of benign prostatic hyperplasia" 18 : 3576-3589, 2011
표고버섯이 고지방식이로 유도한 비만 흰쥐에 미치는 항비만 효과
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
2014-06-24 | 학회명변경 | 한글명 : 한국식품영양과학회지 -> 한국식품영양과학회영문명 : Journal of the Korean Society of Food Science and Nutrition -> The Korean Society of Food Science and Nutrition | |
2014-04-02 | 학회명변경 | 한글명 : 한국식품영양과학회 -> 한국식품영양과학회지영문명 : 미등록 -> Journal of the Korean Society of Food Science and Nutrition | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2005-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2002-07-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2000-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 1.03 | 1.03 | 1.13 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
1.18 | 1.2 | 1.993 | 0.21 |