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      KCI등재 SCOPUS

      Alloxan 당뇨쥐(제1형 당뇨병 모델)와 OLETF 쥐(제2형 당뇨병 모델)에서 녹차 추출물의 고혈당 억제 효과 = Antihyperglycemic Effects of Green Tea Extract on Alloxan-Induced Diabetic and OLETF Rats

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      https://www.riss.kr/link?id=A103699596

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      국문 초록 (Abstract)

      녹차 추출물이 당뇨병의 고혈당에 미치는 영향을 알아보기 위하여 1형 당뇨병 모델인 alloxan 당뇨쥐와 2형 당뇨병모델인 OLETF 쥐에 녹차 추출물을 4주간 투여하면서 혈당을 측정하여 관찰하였...

      녹차 추출물이 당뇨병의 고혈당에 미치는 영향을 알아보기 위하여 1형 당뇨병 모델인 alloxan 당뇨쥐와 2형 당뇨병모델인 OLETF 쥐에 녹차 추출물을 4주간 투여하면서 혈당을 측정하여 관찰하였다. 녹차 추출물 투여 후 1주, 2주, 3주 및 4주째에 꼬리 정맥에서 혈당을 측정한 결과 alloxan 당뇨쥐는 대조군에 비하여 각각 혈당이 161, 176, 177 및 181 mg/dL가 감소되었고, OLETF 쥐는 녹차 추출물 투여군이 대조군에 비하여 각각 28, 33, 38 및 28 mg/dL가 감소되어, 녹차 추출물 투여로 1형 당뇨병인 alloxan 당뇨쥐와 2형 당뇨병인 OLETF 쥐에서 모두 투여 1주일째부터 혈당의 증가 둔화가 나타나서 4주째까지 지속되었다. 녹차 추출물이 당뇨쥐의 식이섭취량 및 체중에 미치는 영향을 알아보기 위하여 실험동물에 녹차 추출물을 투여한 후 1주일 간격으로 식이소모량과 체중을 4주까지 측정한 결과, 식이소모량은 alloxan당뇨쥐와 OLETF 쥐에서 모두 대조군과 녹차 추출물 투여군 사이에 변화가 없었다. 녹차 추출물 투여 당뇨쥐에서혈청 중성지질량의 변화를 관찰한 결과 alloxan 당뇨쥐와 OLETF 쥐에서 모두 녹차 추출물 투여로 중성지질량의 변화가 없었다. 녹차 추출물 투여로 인한 조직세포 손상정도를 측정하기 위하여 alloxan 당뇨쥐와 OLETF 쥐를 대조군과 녹차 추출물 투여군으로 나누어 4주간 사육한 후 혈청 AST 활성도를 측정한 결과 녹차 추출물 투여로 혈청 AST 활성도 변화는 관찰되지 않았다. 이상의 실험 결과로 녹차 추출물을 당뇨병 쥐에 경구투여하면 혈당증가 억제효과가 나타나는데, 녹차 추출물의 혈당증가 억제효과는 1형이나 2형당뇨병 등 당뇨병의 형태와 상관없이 작용할 수 있는 것으로생각된다. 따라서 녹차 추출물은 당뇨병 치료를 위한 우수한 식사요법 보조제로 개발될 수 있을 것으로 기대된다. 또한 녹차 추출물에 함유된 혈당강하작용 물질의 검색과 작용 기전, 특성에 대한 연구가 계속된다면 우수한 혈당강하작용을 가진 물질이 개발될 수 있을 것으로 추측된다.

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      다국어 초록 (Multilingual Abstract)

      This study was performed to investigate the antihyperglycemic effect of green tea extracts (GTE) in diabetic rats. Experimental animals used were alloxan-induced diabetic Sprague-Dawley (SD) rats; as a model of type 1 diabetes mellitus and Otsuka Long...

      This study was performed to investigate the antihyperglycemic effect of green tea extracts (GTE) in diabetic rats. Experimental animals used were alloxan-induced diabetic Sprague-Dawley (SD) rats; as a model of type 1 diabetes mellitus and Otsuka Long Evans Tokushima fatty (OLETF) rats, and as a model of type 2 diabetes mellitus. Animals were randomly assigned either to continue the ad libitum diet or begin a green tea extracts (GTE) contained diet. GTE extracted from green tea was supplemented in the diet (2%). Body weight, food intake, and blood glucose concentration were recorded for 4 weeks. Animals were killed and glucose, triglyceride, and asparate aminotransferase (AST) were analysed in blood. Food intake was not affected by GTE in both alloxan.induced diabetic and OLETF rats but body weight was slightly decreased by GTE in OLETF rats. The blood glucose concentration was markedly decreased by GTE supplementation in both alloxan-induced diabetic and OLETF rats; however, triglyceride and AST levels in serum of GTE treated animals were not changed. This study shows that GTE beneficially modulate blood glucose concentration in diabetic animals. Dietary supplementation with GTE could potentially contribute to nutritional strategies for the treatment of diabetes mellitus.

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      참고문헌 (Reference)

      1 Yamabe N, "Therapeutic potential of(-)-epigallocatechin 3-O-gallate on renal damage in diabetic nephropathy model rats" 319 : 228-236, 2006

      2 Kim YS, "The kinetics of non-enzymatic reaction in green tea during storage at different water activities and temperature" 17 : 226-232, 1988

      3 Sakurai T, "Superoxide production from nonenzymatically glycated protein" 236 : 406-410, 1988

      4 Kawano K, "Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain" 41 : 1422-1428, 1992

      5 Schwarz PE, "Report from the Congress of the American Diabetes Association(ADA)" 113 : 475-479, 2005

      6 Ko YS, "Quantitative analysis of free amino acids and free sugars in steamed and roasted green tea by HPLC" 14 : 301-304, 1985

      7 Kim SM, "Prevalence of diabetes and impaired fasting glucose in Korea : Korean National Health and Nutrition Survey 2001" 29 : 226-231, 2006

      8 Scott FW, "Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells" 46 : 589-598, 1997

      9 Rosen P, "Oxidative stress in young Zucker rats with impaired glucose tolerance is diminished by acarbose" 38 : 575-586, 2006

      10 Krentz AJ, "Oral antidiabetic agents : current role in type 2 diabetes mellitus" 65 : 385-411, 2005

      1 Yamabe N, "Therapeutic potential of(-)-epigallocatechin 3-O-gallate on renal damage in diabetic nephropathy model rats" 319 : 228-236, 2006

      2 Kim YS, "The kinetics of non-enzymatic reaction in green tea during storage at different water activities and temperature" 17 : 226-232, 1988

      3 Sakurai T, "Superoxide production from nonenzymatically glycated protein" 236 : 406-410, 1988

      4 Kawano K, "Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain" 41 : 1422-1428, 1992

      5 Schwarz PE, "Report from the Congress of the American Diabetes Association(ADA)" 113 : 475-479, 2005

      6 Ko YS, "Quantitative analysis of free amino acids and free sugars in steamed and roasted green tea by HPLC" 14 : 301-304, 1985

      7 Kim SM, "Prevalence of diabetes and impaired fasting glucose in Korea : Korean National Health and Nutrition Survey 2001" 29 : 226-231, 2006

      8 Scott FW, "Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells" 46 : 589-598, 1997

      9 Rosen P, "Oxidative stress in young Zucker rats with impaired glucose tolerance is diminished by acarbose" 38 : 575-586, 2006

      10 Krentz AJ, "Oral antidiabetic agents : current role in type 2 diabetes mellitus" 65 : 385-411, 2005

      11 Kawano K, "OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain" 24 : S317-S320, 1994

      12 Mandel SA, "Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway" 14 : 46-60, 2005

      13 Beltz LA, "Mechanisms of cancer prevention by green and black tea polyphenols" 6 : 389-406, 2006

      14 Krauss RM., "Lipids and lipoproteins in patients with type 2 diabetes" 27 : 1496-1504, 2004

      15 Watanabe J, "Isoiation and identification of acetyl-CoA carboxylase inhibitors from green tea(Camellia sinensis)" 62 : 529-534, 1998

      16 Arimoto-Kobayashi S, "Inhibitory effects of(-)-epigallocatechin gallate on the mutation, DNA strand cleavage, and DNA adduct formation by heterocyclic amines" 51 : 5150-5153, 2003

      17 Corns CM, "Herbal remedies and clinical biochemistry" 40 : 489-507, 2003

      18 Tapsell LC, "Health benefits of herbs and spices: the past, the present, the future" 185 : S4-24, 2006

      19 Shirai T, "Green tea-induced asthma : relationship between immunological reactivity, specific and non-specific bronchial responsiveness" 33 : 1252-1255, 2003

      20 Ahmad N, "Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells" 89 : 1881-1886, 1997

      21 Alschuler L, "Green tea : healing tonic" 5 : 28-31, 1998

      22 Mullarkey CJ, "Free radical generation by early glycation prodeucts : a mechanism for accelerated atherogenesis in diabetes" 173 : 932-939, 1990

      23 Wolfram S, "Epigallocatechin gallate supplementation alleviates diabetes in rodents" 136 : 2512-2518, 2006

      24 Dullo AG, "Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation and fat oxidation in humans" 70 : 1040-1045, 1999

      25 Wada R, "Effects of long-term treatment with alpha-glucosidase inhibitor on the peripheral nerve function and structure in Goto-Kakizaki rats: a genetic model for type 2 diabetes" 15 : 332-337, 1999

      26 Ryu OH, "Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients" 71 : 356-358, 2006

      27 Janle EM, "Effect of long-term oral administration of green tea extract on weight gain and glucose tolerance in Zucker diabetic (ZDF) rats" 5 : 55-65, 2005

      28 Diepvens K, "Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females" 94 : 1026-1034, 2005

      29 Brunzell JD, "Dyslipidemia in the metabol-ic syndrome and type 2 diabetes mellitus" 115 : 24S-28S, 2003

      30 Kim JY, "Diabetes and traditional medicine effect of several traditional drug on the plasma glucose levels in streptozotocin-induced diabetic rat" 18 : 377-380, 1994

      31 Sang Youl Rhee, "Diabcare Asia 2001-Korea : Country Report on Outcome Data and Analysis" 대한내과학회 20 (20): 48-54, 2005

      32 Vega P, "Comparison of alloxan and streptozotocin induced diabetes in rats : differential effects on microsomal drug metabolism" 24 : 489-495, 1993

      33 Cabrera C, "Beneficial effects of green tea : a review" 25 : 79-99, 2006

      34 Hosoda K, "Antihyperglycemic effect of oolong tea in type 2 diabetes" 26 : 1714-1718, 2003

      35 Rabinovitch A., "Animal models of type 1 diabetes are relevant to human IDDM" 14 : 189-190, 1998

      36 Azuma K, "Acarbose, an alpha-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation" 345 : 688-693, 2006

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      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2014-06-24 학회명변경 한글명 : 한국식품영양과학회지 -> 한국식품영양과학회
      영문명 : Journal of the Korean Society of Food Science and Nutrition -> The Korean Society of Food Science and Nutrition
      KCI등재
      2014-04-02 학회명변경 한글명 : 한국식품영양과학회 -> 한국식품영양과학회지
      영문명 : 미등록 -> Journal of the Korean Society of Food Science and Nutrition
      KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2005-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2002-07-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2000-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.03 1.03 1.13
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.18 1.2 1.993 0.21
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