한국인 급성 바이러스성 간염의 원인 = The Etiology of Acute Viral Hepatitis in Korean한국인 급성 바이러스성 간염의 원인

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

In order to evaluate the etiology of acute viral hepatitis in Korea where HRV infection is common, HBsAg and IgM anti-HBc were tested in 292 patients with acute viral hepatitis. In addition 1gM anti-HAV and anti-delta were tested according to the result of HbsAg and IgM anti-HBc. The results were as follows; 1) Among 209 patients with HBsAg-positive acute viral hepatitis, 159 (76%) were IgM anti-HBc positive and confirmed as acute hepatitis B. Among 50 IgM anti-HRc negative patients, 9(18%) had superinfection with hepatitis A, 12 (24%) confirmed as hepatitis B by subsequent seroconversion during follow up. The rest 29(58 %) were all anti-delta negative and could be considered as non-A, non-B hepatitis in HBV carrier. 2) Among 83 patients with HRsAg-negative acute viral hepatitis, 46 (55%) had hepatitis A, 14 (17%) had hepatitis B, and 23 (28A ) had presumable non-A, non-B hepatitis. 3) Among total 292 patients with acute viral heaptis, hepatitis A were 55 (19%), hepatitis B were 185 (63%), the presumable non-A, non-B hepatitis were 52 (18%). 4) The overall sexual ratio of male to female was 1.4:1. While hepatitis A was most common in teenagers, hepatitis R and non-A, non-B hepatitis were in 20's. There was no seasonal variation but hepatitis A tended to occur in spring and winter. It is suggested that in Korea where carrier rate of HBsAg is high, the simple presence or absence of HBsAg in aucte viral hepatitis dose not always mean type B or non-B etiology, and accurate serologic diagnosis of acute viral heaptitis requires testing for HbsAg and IgM anti-HBc.