<P>A series of novel 5'(7')-substituted-2'-oxospiro[1,3] dioxolane-2,3'-indoline-based N-hydroxypropenamides were designed, synthesized and evaluated for histone deacetylase (HDAC) inhibition and cytotoxicity. It was found that the compounds in ...
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=A107433463
Dung, D.T.M. ; Dung, P.T.P. ; Oanh, D.T.K. ; Vu, T.K. ; Hahn, H. ; Han, B.W. ; Pyo, M. ; Kim, Y.G. ; Han, S.B. ; Nam, N.H.
2017
-
SCOPUS,SCIE
학술저널
465-472(8쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>A series of novel 5'(7')-substituted-2'-oxospiro[1,3] dioxolane-2,3'-indoline-based N-hydroxypropenamides were designed, synthesized and evaluated for histone deacetylase (HDAC) inhibition and cytotoxicity. It was found that the compounds in ...
<P>A series of novel 5'(7')-substituted-2'-oxospiro[1,3] dioxolane-2,3'-indoline-based N-hydroxypropenamides were designed, synthesized and evaluated for histone deacetylase (HDAC) inhibition and cytotoxicity. It was found that the compounds in this series displayed potent inhibitory effects against HDAC2 with IC50 values as low as 0.284 mu M, almost comparable to that of SAHA (IC50, 0.265 mu M), a positive control. In Western blot analysis, these compounds also exhibited noted inhibition toward histone deacetylation and this inhibition was found to correlate well with the cytotoxicity of the compounds in three human cancer cell lines. Docking studies indicated the compounds in this series bound to HDAC2 with high binding affinities (similar to -9.8 kcal/mol) compared to SAHA (-7.4 kcal/mol). (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.</P>