Effect of Near Infrared Irradiation on the Dentin-pulp Complex in Vivo = Effect of Near Infrared Irradiation on the Dentin-pulp Complex in Vivo

다국어 초록 (Multilingual Abstract)

The clinical adoption of resident-stem-cell-based dental regeneration will require the use of physical cues. Here, we tested the hypothesis that exposure of near infrared (NIR) light can produce forming reactionary dentin beneath a calciotraumatic line at the junction between a tubular dentin and odontoblast layer in normal teeth of a beagle. As assessed by micro-computed tomography analysis, reactionary dentin formation was produced up to 20 % increments after 8 weeks of exposure to NIR compared to a control that was not exposed to NIR. Additionaly, It was observed that odontoblasts subjected to NIR light exposure were active, generating new tubular dentin that lined older dentin in SEM analysis. Notably, active odontoblasts were not observed in controls, even though an odontoblast-like layer in the dentin structure was visible in SEM analysis. This might be due to cell signaling molecules and vasculature activated by NIR irradiation. This result suggest that such a strategy might facilitate treatments relating to diseases of dentin in mature permanent teeth.